Sökning: "personalised medicine"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden personalised medicine.

1. 1. Study of Resistance in Hepatitis C Virus Prior to Treatment with Direct Acting Antivirals

   Författare :Midori Kjellin; Johan Lennerstrand; Nina Weis; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C; HCV; DAA; RAS; resistance-associated substitution; baseline resistance; NS5A; NS3; SVR; Medical Virology; Medicinsk virologi; Mikrobiologi; Microbiology; Infektionssjukdomar; Infectious Diseases;

   Sammanfattning : The rapid advancement of Hepatitis C (HCV) treatment presents a great challenge to clinicians in optimising therapy for their patients. Genotype (GT), efficacy, side-effects, drug combinations and treatment durations must be tailored to individual patients, considering comorbidities, degree of fibrosis, adherence and antiviral resistance. LÄS MER

3. 2. Improving prognostication and treatment choices for patients with AML

   Författare :Albin Österroos; Sören Lehmann; Marc H G P Raaijmakers; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukaemia; Acute promyelocytic leukaemia; Prognostication; Personalised medicine; Risk stratification; Real-world data; Next-generation sequencing; Azacitidine; Venetoclax; Medicinsk vetenskap; Medical Science;

   Sammanfattning : The treatment landscape of the aggressive haematological malignancy acute myeloid leukaemia (AML) has expanded but the prognosis is still unsatisfactory poor. Here, we aimed at improving prognostication and treatment choices in AML by addressing current clinical obstacles to successful AML treatment. LÄS MER

4. 3. Circulating platelets : a novel liquid biopsy source for cancer diagnostics and therapy stratification

   Författare :Lee-Ann Tjon-Kon-Fat; Jonas Nilsson; Pernilla Wikström; Michiel Pegtel; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; biomarkers; liquid biopsy; therapy stratification; personalised medicine; Prostate cancer;

   Sammanfattning : As conventional tissue biopsies have several drawbacks, much effort has been directed toward the development of minimal-invasive liquid biopsy platforms for detecting and profiling cancer.Platelets are the second most abundant cells in blood and have very versatile functions both in physiological and pathophysiological conditions. LÄS MER

5. 4. Epidemiological aspects of drug-related vitamin D deficiency and osteoporotic fractures

   Författare :Ola Nordqvist; Martin Carlsson; Pär Wanby; Thomas Neumark; Björn Wettermark; Linnéuniversitetet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vitamin D; secondary osteoporosis; fractures; drug risk management; medical guideline adherence; electronic health records; real-world data; risk assessment; awareness; attitudes; personalised medicine; cross-sectional study; cohort study; qualitative analysis; thematic analysis; pharmacoepidemiology; Biomedical Sciences; Biomedicinsk vetenskap;

   Sammanfattning : Background: Vitamin D deficiency, secondary osteoporosis and low-energy fractures (LEF) as side effects of specific drugs were first described more than half a century ago. These effects are recognized in guidelines where patients prescribed risk drugs are recommended follow-up with testing and supplementation. LÄS MER

7. 5. Methodological approaches towards personalised cancer medicine

   Författare :Michael Mints; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Despite advances in diagnostics and treatments, many cancer patients have poor survival rates. Tumours develop drug resistance followed by metastasis, and survivors suffer from treatment side-effects. LÄS MER