Sökning: "unique molecular identifiers"
Hittade 4 avhandlingar innehållade orden unique molecular identifiers.
1. Next generation molecular diagnostics using ultrasensitive sequencing
Sammanfattning : Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to revolutionize molecular diagnostics. LÄS MER
2. Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine
Sammanfattning : Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid biopsies, cell-free DNA is present at low concentrations, contains minute tumor allele frequencies, and is highly fragmented. LÄS MER
3. Counting molecules in cell-free DNA and single cells RNA
Sammanfattning : The field of Molecular Biology got started in earnest with the discovery of the molecular structure of DNA. This lead to a surge of interest into the relationships between DNA, RNA and proteins, and to the development of fundamental tools for manipulating those substances, such as cutting, ligating, amplifying, visualizing and size-selecting DNA. LÄS MER
4. Applications of genomic tools to decode genome function
Sammanfattning : The revolution in sequencing technologies has greatly advanced our understanding of genomes. Many regulatory elements lacking protein-coding ability, such as long non-coding RNAs have been identified and characterized in different biological contexts. LÄS MER