Sökning: "glucose signalling"

Visar resultat 6 - 10 av 107 avhandlingar innehållade orden glucose signalling.

1. 6. Dynamic regulation of the Mig1 transcriptional repressor under glucose de/repression

   Författare :Sviatlana Shashkova; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell signalling; glucose repression; Mig1; phosphorylation; Saccharomyces cerevisiae;

   Sammanfattning : The budding yeast Saccharomyces cerevisiae AMP-activated protein kinase/SNF1 is a member of a highly conserved protein family present in all eukaryotes. Snf1 regulates energy homeostasis; in yeast, it is best-known for its role in cellular adaptation to glucose limitation. LÄS MER

3. 7. Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals

   Författare :Loubna Bendrioua; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; AMPK; SNF1; Mig1; glucose signalling; dynamic control; mechanism; Saccharomyces cerevisiae;

   Sammanfattning : The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing energy-generating and damping energy-requiring processes. LÄS MER

4. 8. Insulin promotes GABA signalling modulation in both the mouse hippocampus and human CD4+ T cells

   Författare :Hayma Hammoud; Bryndis Birnir; Fredrik Elinder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gamma-aminobutyric acid; hippocampus; tonic currents; CD4 T cells; glucose; insulin; cytokines; proliferation.; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Gamma-aminobutyric acid (GABA) is the most common inhibitory neurotransmitter in the adult mammalian brain, where it mediates several biological functions. Rapid inhibition is predominantly mediated by the activation of GABA-A receptors that are ubiquitously expressed across the central nervous system in a cell-, circuit-, or region-specific manner. LÄS MER

5. 9. α-Cell signalling in glucose-regulated glucagon secretion

   Författare :Qian Yu; Anders Tengholm; Erik Gylfe; Sebastian Barg; David W Piston; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islets; glucagon; insulin; somatostatin; ATP; cAMP; Ca2 ; GHB; oscillations; α-cell; β-cell; δ-cell; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Glucagon is a blood glucose-elevating hormone released from α-cells in the islets of Langerhans during hypoglycaemia. Glucagon is critical for glucose homeostasis and inappropriate regulation of its secretion underlies both impaired counter-regulation of hypoglycaemia and chronic hyperglycaemia in diabetes patients. LÄS MER

7. 10. Dynamic single-cell modelling of nutrient signalling in budding yeast

   Författare :Sebastian Persson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nutrient signalling; single-cell; mixed-effects models; stochastic dynamic models; Bayesian inference;

   Sammanfattning : To survive in environments with constantly changing nutrient levels the bud- ding yeast Saccharomyces cerevisiae has a sophisticated nutrient sensing system. A central component of this system is the SNF1 signalling pathway, which primarily helps yeast adapt to glucose limited conditions. LÄS MER