Sökning: "Fredrik Elinder"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Fredrik Elinder.

  1. 1. Voltage-dependent anion channels (VDAC) in the plasma membrane induce apoptosis

    Författare :Nesar Akanda; Fredrik Elinder; Tuula Jalonen; Linköpings universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Physiology; Apoptosis; Cell membrane; Hippocampus; Membrane potentials; Neurons; Voltage-dependent anion channels; Medicine; Medicin;

    Sammanfattning : Apoptosis, or programmed cell death, is essential for proper development and functioning of the body systems. During development, apoptosis plays a central role to sculpt the embryo, and in adults, to maintain tissue homeostasis by eliminating redundant, damaged or effete cells. Therefore, a tight regulation of this process is essential. LÄS MER

  3. 2. Molecular aspects on voltage-sensor movement

    Författare :Amir Broomand; Fredrik Elinder; Guiscard Seebohm; Linköpings universitet; []
    Nyckelord :Potassium channels; voltage-gated; chemistry; metabolism; physiology; patch-clamp techniques; oocytes; MEDICINE; MEDICIN;

    Sammanfattning : Voltage-gated ion channels are fundamental for electrical signaling in living cells. They are composed of four subunits, each holding six transmembrane helices, S1-S6. Each subunit contains a voltage-sensor domain, S1-S4, and a pore domain, S5-S6. LÄS MER

  4. 3. Polyunsaturated Fatty Acids Modifying Ion Channel Voltage Gating

    Författare :Sara Börjesson; Fredrik Elinder; Klaus Benndorf; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Voltage-gated ion channels play fundamental roles in neuronal excitability and therefore dysfunctional channels can cause disease. Epilepsy is such a disease, affecting about 1% of the population and being characterized by synchronous electric activity of large groups of neurons leading to various types of seizures. LÄS MER

  5. 4. Brain Networks and Dynamics in Narcolepsy

    Författare :Natasha Morales Drissi; Maria Engström; Gunnar Cedersund; Fredrik Elinder; Birgitte Kornum; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Narcolepsy is a chronic sleep disorder, characterised by excessive daytime sleepiness with frequent uncontrollable sleep attacks. In addition to sleeprelated problems, changes in cognition have also been observed in patients with narcolepsy and has been linked to the loss of Orexin-A in a number of studies. LÄS MER

  7. 5. The role of ion channels and intracellular metal ions in apoptosis of Xenopus oocytes

    Författare :Ulrika Englund; Fredrik Elinder; Johan Brask; Katarina Kågedal; Dan Klaerke; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Apoptosis is one type of programmed cell death, important during tissue development and to maintain the tissue homeostasis. Apoptosis comprises a complex network of internal signaling pathways, and an important part of this signaling network is the action of voltage‐gated ion channels. LÄS MER