Sökning: "autocrine loop"
Visar resultat 1 - 5 av 20 avhandlingar innehållade orden autocrine loop.
1. Molecular studies of genetic changes in myxoid and round cell liposarcoma
Sammanfattning : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. LÄS MER
2. Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth
Sammanfattning : Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. LÄS MER
3. Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas
Sammanfattning : Human islet transplantation is emerging as an alternative to pancreas transplantation or insulin therapy in the treatment of type I diabetes. It has been possible to achieve euglycemia by transplanting isolated human islets in patients who suffer from the long term side effects of diabetes and insulin therapy. LÄS MER
4. Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
Sammanfattning : The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. LÄS MER
5. Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo
Sammanfattning : Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. LÄS MER