Sökning: "persephin"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet persephin.
1. Molecular studies of genetic changes in myxoid and round cell liposarcoma
Sammanfattning : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. LÄS MER
2. Glial cell line-derived neurotrophic factor : expression patterns, neuronal transport, regulation, effects, and receptor dependence
Sammanfattning : Background: The mammalian nervous system depends upon trophic proteins for survival, growth and adult maintenance. These trophic factors have also been considered as potential therapeutic agents for treating human neurodegenerative disorders. LÄS MER
3. GDNF family ligands and neural stem cells in Parkinson's disease
Sammanfattning : Parkinson's disease (PD) is a very common neurodegenerative disorder, characterized by a progressive degeneration of mainly nigrostriatal and mesolimbic dopaminergic neurons leading to tremor, rigidity and hypokinesia, the classical symptoms of the disease. Degeneration of noradrenergic neurons of the locus coeruleus are also involved in the progression of the disease, causing dementia and depression. LÄS MER
4. Expression and function of GDNF family ligands and receptors in the nervous system
Sammanfattning : The search for novel neurotrophic factors promoting dopamine uptake and the survival of central dopaminergic neurons led to the discovery of a novel neurotrophic factor termed glial cell-line derived neurotrophic factor (GDNF). GDNF, neurturin (NTN), artemin (ART) and persephin (PSP) belong to the GDNF family ligands, and are potent survival-promoting factors for subsets of central and peripheral neurons. LÄS MER
5. GDNF and its receptors : a structure-function analysis of the NCAM-GDNF-GFRalpha1 complex and an examination of potential receptor candidates
Sammanfattning : Neurotrophic factors are small, secreted proteins that are important players in the development and maintenance of the nervous system. Their functions span from neuronal survival and migration to neurite outgrowth and axon guidance, and in some cases even programmed cell death. LÄS MER