Sökning: "IGFs"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet IGFs.

  1. 1. Novel insulin-like growth factor-binding protein proteases : detection and characterization

    Författare :Jing Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGFs; IGFBP-1. IGFBP-3; azurocidin HBP CAP37; IGFBP protease; gender;

    Sammanfattning : Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins (IGFBP-1 to -6) control the availability of IGFs (IGF-I and IGF-II) to their receptors. LÄS MER

  3. 2. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

  4. 3. Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis

    Författare :Eugenia Colón; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGFs; steroidogenesis; Leydig cells; steroidogenic acute regulatory protein StAR ; insulin; IGFBP-3; IGFBP-2 and steroidogenic enzymes;

    Sammanfattning : The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. LÄS MER

  5. 4. Insulin resistance and IGF-I sensitivity in vascular cells - impact of hybrid receptors : With special regard to diabetes

    Författare :Git Johansson; Hans Arnqvist; Pierre De Meyts; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Diabetic complications largely affect the circulation and are associated with resistance to insulin and altered levels of insulin-like growth factor-I (IGF-I). Insulin resistance and altered IGF-I levels are also associated with vascular disease. LÄS MER

  7. 5. Osteoporosis in chronic liver disease

    Författare :Sif Ormarsdóttir; Uppsala universitet; []
    Nyckelord :Medical sciences; Chronic liver disease; bone mineral density; osteoporosis; body mass index; corticosteroids; hyperbilirubinemia; vitamin D; insulin-like growth factors; leptin; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Ormarsdóttir, S. 2001. Osteoporosis in Chronic Liver Disease. Acta Universitatis Upsaliensis. LÄS MER