Sökning: "Leydig cells"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Leydig cells.

  1. 1. Identification and characterization of stem Leydig cells in the testis

    Författare :Luise Landreh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the testis, several cell types are needed to ensure male fertility, among them the testosterone-producing Leydig cells. Testosterone supports the maturation of sperm and maintains the male phenotype. Functional Leydig cells are therefore required to prevent testicular malfunction. LÄS MER

  3. 2. Hormone-Sensitive Lipase and Protein Kinase B; Molecular characterization in testis, adipose tissue and pancreatic beta cells

    Författare :Lena Stenson; Signaltransduktionsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; signal transduction; pancreas; beta cells; adipocyte; insulin; Akt; protein kinase B; spermatogenesis; cholesterol esterase; hormone-sensitive lipase; testis; cAMP; Proteins; enzymology; Proteiner; enzymologi;

    Sammanfattning : Hormone-sensitive lipase (HSL) and protein kinase B (PKB) are enzymes that in different ways are associated with lipid metabolism. While HSL is the well-known lipolytic enzyme responsible for hydrolysis of stored triacylglycerols in adipose tissue, PKB is a recently identified serine/threonine protein kinase, ubiquitously expressed and involved in signal transduction pathways induced by insulin and growth factors. LÄS MER

  4. 3. Effects of endocrine disruptors on adreno-cortical and Leydig cell steroidogenesis

    Författare :Vichit Supornsilchai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endocrine disrupting chemicals EDCs ; steroidogenesis; Leydig cells; adrenocortical cells; steroidogenic acute regulatory protein StAR ; steroidogenic enzymes;

    Sammanfattning : A common sequential pathway for steroidogenesis, designed to produce steroid hormones, is expressed in the adrenal cortex, testes and ovaries. In this process, cholesterol is converted to all known steroids by specific enzymes in a tissue-specific manner. LÄS MER

  5. 4. Hormonal and paracrine influences on Leydig cell steroidogenesis

    Författare :Nina Renlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Androgen production by Leydig cells is critical for development of the male reproductive organs and for maintaining normal body homeostasis and fertility later in life. Biosynthesis of testosterone is driven by secretion of the gonadotropin, luteinizing hormone (LH) from the pituitary. LÄS MER

  7. 5. Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis

    Författare :Eugenia Colón; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGFs; steroidogenesis; Leydig cells; steroidogenic acute regulatory protein StAR ; insulin; IGFBP-3; IGFBP-2 and steroidogenic enzymes;

    Sammanfattning : The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. LÄS MER