Sökning: "T Jansson"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden T Jansson.

1. 1. On the role of nitric oxide in bladder cancer and renal cell carcinoma

   Författare :Olof T Jansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :urogenital tract; renal cell; transitional cell; carcinoma; nitric oxide; nitric oxide synthase; cytokines; apoptosis; BCG; cystitis;

   Sammanfattning : The role of nitric oxide (NO) in tumour biology is unclear. There are conflicting reports in the literature whether NO will promote or inhibit tumour growth. The aim of the present thesis was to investigate the role of NO in bladder cancer and renal cell carcinoma. LÄS MER

3. 2. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

   Författare :Anna M. Jansson; T. Alwyn Jones; Sherry L. Mowbray; E. Yvonne Jones; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. LÄS MER

4. 3. Capillary electrophoresis mass spectrometry applied to structural proteomics and small molecule analysis

   Författare :Jordan Aerts; Erik T. Jansson; Per E. Andrén; Petr Man; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Capillary Electrophoresis Mass Spectrometry; Hydrogen Deuterium Exchange Mass Spectrometry; Enantioselective Separations; Drugs of Abuse; Analytical Chemistry; Analytisk kemi; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

   Sammanfattning : Capillary electrophoresis with mass spectrometric (CE–MS) detection offers a separation method without equal in terms of flexibility, utility, and cost efficiency. Here we demonstrate precisely this through the application of several laboratory-built CE–MS instruments for the separation of brain metabolites in non-primates, enantioselective separations of synthetic anesthetic metabolites in fractionated pony urine, application in structural proteomics workflows, and identification of exogenous alkaloid biotransformationproducts in human cerebrospinal fluid (CSF). LÄS MER

5. 4. Towards a Person-Centric Context Aware System

   Författare :Wei Li; Carl Gustaf Jansson; Mark T. Smith; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Telecommunication; Telekommunikation;

   Sammanfattning : A recent trend is to integrate sensing, communication, and computation into every aspect of our daily life, ranging from various user devices to physical environment. The goal is to give computer systems an awareness of the users and their situations, so that they can support their diverse interaction needs at anytime, any place. LÄS MER

7. 5. Integrative Approaches in Shotgun Proteomics : From sample preparation to multifaceted data analysis

   Författare :Mariya Nezhyva; Erik T. Jansson; Per Andrén; Gustaf Christoffersson; Jesper Velgaard Olsen; Uppsala universitet; []
   Nyckelord :bottom-up proteomics; thermal proteome profiling; mass-spectrometry imaging; data analysis; melanocortin receptor; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Bottom-up proteomics mass-spectrometry gives an opportunity to shed light on var-ious biological aspects/characteristics such as protein composition, its modifications,interactions, and dynamics. Its applications span a wide range of biological sciencesaiming to eventually answer fundamental disease related questions or evaluate drugperformance and predict adverse effects. LÄS MER