Sökning: "Sherry L. Mowbray"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Sherry L. Mowbray.

1. 1. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

   Författare :Anna M. Jansson; T. Alwyn Jones; Sherry L. Mowbray; E. Yvonne Jones; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. LÄS MER

3. 2. Enzymes in the Mycobacterium tuberculosis MEP and CoA Pathways Targeted for Structure-Based Drug Design

   Författare :Christofer Björkelid; T. Alwyn Jones; Torsten Unge; Sherry L. Mowbray; William N. Hunter; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Tuberculosis; Mycobacterium tuberculosis; MEP pathway; CoA pathway; drug development; crystal structure; DXR; IspD; PanK; Biokemi; Biochemistry; Molecular Biology; Molekylärbiologi;

   Sammanfattning : Tuberculosis, caused by the pathogenic bacteria Mycobacterium tuberculosis, is one of the most widespread and deadly infectious diseases today. Treatment of tuberculosis relies on antibiotics that were developed more than 50 years ago. These are now becoming ineffective due to the emergence of antibiotic resistant strains of the bacteria. LÄS MER

4. 3. Structural and Functional Studies of Peptidyl-prolyl cis-trans isomerase A and 1-deoxy-D-xylulose- 5-phosphate reductoisomerase from Mycobacterium tuberculosis

   Författare :Lena M Henriksson; Torsten Unge; Sherry L. Mowbray; Barbara Seaton; Uppsala universitet; []
   Nyckelord :Molecular biology; Mycobacterium tuberculosis; Rv0009; peptidyl-prolyl cis-trans isomerase; Rv2870c; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; non-mevalonate pathway; DOXP MEP pathway; X-ray crystallography; Molekylärbiologi;

   Sammanfattning : Mycobacterium tuberculosis, the causative pathogen of tuberculosis, currently infects one-third of the world’s population, resulting in two million deaths annually. This clearly shows that tuberculosis is one of the most serious diseases of our times. LÄS MER

5. 4. Structural Studies of Glutamine Synthetases – Towards the Development of Novel Antitubercular Agents

   Författare :Wojciech W. Krajewski; Sherry L. Mowbray; Torsten Unge; Thomas C. Terwilliger; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Structural biology; Strukturbiologi;

   Sammanfattning : Glutamine synthetase (GS) plays an important role in nitrogen metabolism, where it catalyzes the ATP-dependent condensation of glutamate and ammonia to yield glutamine. Recent studies showed the importance of M. tuberculosis GS (MtGS) for growth and survival of the bacterium, and demonstrated its potential as a drug target. LÄS MER

7. 5. Structural and Biochemical Characterizations of Three Potential Drug Targets from Pathogens

   Författare :Lu Lu; Sherry L Mowbray; Alwyn Jones; Christian Cambillau; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LepB; DXR; NDH-2; fosmidomycin; quinolinyl pyrimidine; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

   Sammanfattning : As antibiotic resistance of various pathogens emerged globally, the need for new effective drugs with novel modes of action became urgent. In this thesis, we focus on infectious diseases, e.g. LÄS MER