Sökning: "Biology with specialization in Structural Biology"
Visar resultat 1 - 5 av 46 avhandlingar innehållade orden Biology with specialization in Structural Biology.
1. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors
Sammanfattning : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. LÄS MER
2. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis
Sammanfattning : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. LÄS MER
3. Of spiders, bugs, and men : Structural and functional studies of proteins involved in assembly
Sammanfattning : Protein assembly enables complex machineries while being economical with genetic information. However, protein assembly also constitutes a potential threat to the host, and needs to be carefully regulated.Sulfate is a common source of sulfur for cysteine synthesis in bacteria. LÄS MER
4. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties
Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER
5. Allosteric control of ALC1-catalyzed nucleosome remodeling
Sammanfattning : The genetic information of eukaryotic cells is packaged inside the nucleus as chromatin. This packaging restricts access to the DNA and therefore represents a barrier for processes such as DNA replication, repair, and gene expression. LÄS MER