Sökning: "Capillary Electrophoresis Mass Spectrometry"

Visar resultat 1 - 5 av 53 avhandlingar innehållade orden Capillary Electrophoresis Mass Spectrometry.

  1. 1. Bioanalysis using capillary electrophoresis and mass spectrometry : Applied on proteins, protein nanofibrils and polyvinyl alcohol microbubbles

    Författare :Leila Josefsson; Åsa Emmer; Ulrika Nilsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; : amyloid; capillary electrophoresis; contrast agents; detection; human blood plasma; ionic liquids; mass spectrometry; microbubbles; polyvinyl alcohol microbubbles; protein nanofibrils; proteins; Kemi; Chemistry;

    Sammanfattning : The sequencing of the genome of various species, including the human species, have led to increased understanding about how a protein structure is generated, and how specific structures are related to the proteins’ functionality. In paper I and II of this thesis, the folding of proteins in vitro to form hierarchical nanostructures, which in vivo often have a pathological effect, have been studied. LÄS MER

  3. 2. Metabolic Studies with Liquid Separation Coupled to Mass Spectrometry

    Författare :Erik Allard; Jonas Berguist; Per Sjöberg; Risto Kostiainen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; liquid chromatography; mass spectrometry; tandem mass spectrometry; method development; capillary electrophoresis; electrospray ionization; time-of-flight; quantitation; metabolomics; metabonomics; pattern recognition; ximelagatran; melagatran; charge state; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Metabolism is the sum of all chemical processes with the purpose to maintain life, as well as enable reproduction, in a living organism. Through the study of metabolism, increased understanding of pharmacological mechanisms and diseases can be achieved. LÄS MER

  4. 3. Development of Capillary Electrophoresis Methods Coupled to Mass Spectrometry for Biomedical and Pharmaceutical Analysis

    Författare :Anisa Elhamili; Jonas Bergquist; Magnus Wetterhall; Douglas Westerlund; Alejandro Cifuentes; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Capillary Electrophoresis; Capillary Surface Modificaions; Electrospray Ionization; Mass Spectrometry; Peptides; Intact Proteins; Basic Pharmaceutical Drug Molecules and Complex Biological Samples; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : The analysis of large intact proteins and complex biological samples containing drug molecules is a common complicated task for many scientists. However, due to the importance of these molecules, there is a growing interest in pharmaceutical and medicinal research to develop rapid, highly sensitive and efficient analytical techniques. LÄS MER

  5. 4. Managing and Exploring Large Data Sets Generated by Liquid Separation - Mass Spectrometry

    Författare :Daniel Bäckström; Per Sjöberg; Rolf Danielsson; Thomas Moritz; Uppsala universitet; []
    Nyckelord :Analytical chemistry; liquid chromatography; capillary electrophoresis; capillary electrochromatography; mass spectrometry; electro spray ionization; chemometrics; multivariate data analysis; peptide; biomarkers; fingerprints; PCA; alignment; data compression; ANOVA; target correlation; data management; Analytisk kemi;

    Sammanfattning : A trend in natural science and especially in analytical chemistry is the increasing need for analysis of a large number of complex samples with low analyte concentrations. Biological samples (urine, blood, plasma, cerebral spinal fluid, tissue etc. LÄS MER

  7. 5. Capillary electroseparations with mass spectrometric detection Nanoparticle-based continuous full filling and applications for complex sample matrices

    Författare :Peter Viberg; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytisk kemi; Analytical chemistry; phthalates; continuous full filling; heterocyclic aromatic amines; pseudostationary phase; capillary electrophoresis; electrokinetic chromatography; capillary electrochromatography; nanoelectrospray; mass spectrometry;

    Sammanfattning : One of the major challenges in analytical chemistry is to find techniques and methods for determinations of low abundance compounds in complex sample matrices. This thesis describes the development of new miniaturised analytical techniques comprising capillary electroseparation combined with mass spectrometric detection. LÄS MER