Sökning: "Dissociation constant"

Visar resultat 31 - 35 av 57 avhandlingar innehållade orden Dissociation constant.

  1. 31. High Affinity Synthetic Molecular Binders for Proteins : Design, Synthesis and Evaluation

    Författare :Xiaojiao Sun; Lars Baltzer; Thomas Norberg; Ulf Nilsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide; conjugates; D-dimer; myeloperoxidase; chitinase;

    Sammanfattning : This thesis describes the design and synthesis of small molecule derivatives and their polypeptide conjugates as high affinity binders for proteins: the D-dimer protein (D-dimer), a biomarker for diagnosis of thromboembolic diseases; human myeloperoxidase (MPO), a biomarker for cardiovascular diseases; and chitinases, potential targets for asthma therapy. The interactions between the synthetic binder molecules and those proteins were evaluated by surface plasmon resonance (SPR) biosensor analysis and fluorescence spectroscopy. LÄS MER

  3. 32. NMR studies on interactions between the amyloid β peptide and selected molecules

    Författare :Anna Wahlström; Astrid Gräslund; Göran Karlsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Amyloid β peptide; Alzheimer s disease; Aggregation; Oligomer; Amyloid; Interaction; Nuclear Magnetic Resonance Spectroscopy; Circular Dichroism Spectroscopy; Thioflavin T; Detergent; Congo red; Affibody; Cyclodextrin dimer; Metal ion; Chemistry; Kemi; Biochemistry; Biokemi; Biophysics; biofysik;

    Sammanfattning : Alzheimer’s disease is an incurable neurodegenerative disorder linked to the amyloid β (Aβ) peptide, a 38-43 residue peptide. The detailed molecular disease mechanism(s) is (are) unknown, but oligomeric Aβ structures are proposed to be involved. LÄS MER

  4. 33. Electrochemical Studies of Quinonoid Compounds for Aqueous Organic Redox Flow Batteries

    Författare :Cedrik Wiberg; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Redox Flow Batteries; Naphthalene Diimides; Self-Association; Quinones; Electrochemistry;

    Sammanfattning : In the current times of uncertainty in face of climate change, sustainable energy-related technologies are developed with urgency. A candidate of special interest is Aqueous Organic Redox Flow Batteries (AORFB), whose utility depends heavily on the organic molecules used. LÄS MER

  5. 34. Chemical transformation of the anticancer drug oxaliplatin

    Författare :Elin Jerremalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxaliplatin is a new platinum based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin, both as palliative and adjuvant treatment of metastatic colorectal cancer. Various biotransformation products are formed non-enzymatically after oxaliplatin administration. LÄS MER

  7. 35. Beta-Lactamase in Haemophilus ducreyi: Purification, Characterization, and Mutagenesis

    Författare :Ratana Lawung; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Metabolism; Biochemistry; enzyme calorimeter; site-directed mutagenesis; ampicillin resistance plasmid; Haemophilus ducreyi; TEM-1 b-lactamase; metabolism; Proteins; enzymology; Proteiner; enzymologi; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Chancroid caused by Haemophilus ducreyi, has been described as a significantly predisposing factor of HIV heterosexual transmission in an endemic region of both diseases. Antibiotic resistances are extensively found in H. ducreyi and many of the resistances are due to the presence of resistance plasmids. LÄS MER