Sökning: "B-DNA"

Visar resultat 6 - 10 av 11 avhandlingar innehållade ordet B-DNA.

  1. 6. Nucleic Acids as Drug Targets -Interactions of Platinum Complexes, Polyamines, and siRNA with DNA and RNA Models

    Författare :Margareta Hägerlöf; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kinetics; Kemi; Chemistry; AU-rich region; siRNA; Circular Dichroism; Polyamine; Modified Nucleoside; HPLC; Thermodynamic Stability; cisplatin; Hairpin; DNA and RNA conformation; RNA; DNA; Anticancer Drug; Platinum Complexes;

    Sammanfattning : Drugs targeting nucleic acids were studied in DNA and RNA model systems. The effects were investigated with respect to structural and thermodynamic influence, kinetics, and biological function. The drugs employed in this thesis were anticancer active platinum(II) complexes, polyamine derivatives, and siRNA. LÄS MER

  3. 7. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

    Författare :Mehdi Motallebipour; Claes Wadelius; Gunnar Westin; Dirk Schübeler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcription; ChIP-chip; ChIP-seq; genome-wide; transcription factors; microsatellite; epigenetic; Medical genetics; Medicinsk genetik;

    Sammanfattning : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. LÄS MER

  4. 8. Nuclear Magnetic Relaxation Dispersion and Pulsed-Gradient Spin Echo Studies of Biomolecular Solutions and Amphiphilic Liquid Crystals

    Författare :Haukur Jóhannesson; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stretched dispersion; DNA hydration; solvent dynamics; NMRD; Random flight simulation; PGSE; Diffusion; Nematic phase; NMR; Amphiphilic liquid crystals; Physical chemistry; Fysikalisk kemi;

    Sammanfattning : Biomolecular solutions and amphiphilic liquid crystals are studied by Nuclear Magnetic Resonance Dispersion (NMRD) and Pulsed-Gradient Spin Echo (PGSE) respectively. A random-flight simulation is performed to obtain the obstructing factors for self-diffusion of small molecules in macrofluids. LÄS MER

  5. 9. Anti-gene oligonucleotides : DNA binding and therapeutic application

    Författare :Tea Umek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The field of nucleic acid therapeutics has in the last decade experienced substantial growth. This is evident from a multitude of new publications, an increasing number of clinical trials and several approved therapeutics on the market. LÄS MER

  7. 10. Expression and function of vascular estrogen receptors alpha and beta

    Författare :Min Liang; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetologi; diabetology; Endokrinologi; sekretion; ubiquitin-proteasome pathway; MIP-2; MCP-1; iNOS; estrogen receptor knockout; estrogen receptor; aorta; estrogen;

    Sammanfattning : Estrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. LÄS MER