Sökning: "estrogen receptor knockout"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden estrogen receptor knockout.
1. Expression and function of vascular estrogen receptors alpha and beta
Sammanfattning : Estrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. LÄS MER
2. Factors Contributing to Detrusor Overactivity - Obstruction, Hypertrophy and Afferent Nerve Stimulation
Sammanfattning : The consequences of bladder outlet obstruction (BOO) with respect to detrusor hypertrophy, structural and functional changes, and obstruction-induced detrusor overactivity were investigated in vivo and in vitro utilizing various animal models. Possible pathophysiological pathways and therapeutic approaches were tested by drug treatment and the use of knockout models. LÄS MER
3. Arthritis and immune-mediated bone loss - role of estrogen signalling pathways
Sammanfattning : Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and progression of experimental RA but also the immune-mediated bone loss. LÄS MER
4. Pharmacological Modulation of Skeletal Homeostasis
Sammanfattning : Both ovariectomy (OVX) and gastrectomy (GX) cause osteopenia in several animal species including humans. While the effect of OVX has been ascribed to estrogen deficiency, the underlying mechanism behind GX-induced osteopenia is poorly understood. LÄS MER
5. Nuclear receptor functions in the central nervous system : clues from knockout mice
Sammanfattning : The nuclear receptor (NR) superfamily is the largest known family of transcription factors in eukaryotes. In the 1980 s when the size of the NR family and the scope of the functions of its members were being discovered, tissue distribution studies revealed that the mRNAs of many of these receptors were expressed in the central nervous system. LÄS MER