Sökning: "vesicle aggregation"

Visar resultat 6 - 10 av 16 avhandlingar innehållade orden vesicle aggregation.

  1. 6. α-Synuclein Fibril Formation and the Effects of Lipid Membranes

    Författare :Ricardo Gaspar; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; alpha-synuclein; Parkinson s disease; microscopic rate constants; Thioflavin T; ganglioside lipids; Exosomes; protein-lipid co-aggregation; model membranes; monomer-dependent secondary nucleation;

    Sammanfattning : Amyloid protein aggregation results in major disturbances of cellular processes in humans. The most common amyloid-related disorders are Alzheimer´s disease and Parkinson´s disease. Parkinson´s disease is charaterized by the formation of protein-rich aggregates that are deposited in neurons, termed Lewy bodies and Lewy neurites. LÄS MER

  3. 7. α-synuclein interactions with lipid membranes

    Författare :Katarzyna Makasewicz; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; alpha-Synuclein; lipid membranes; protein-lipid interactions; binding cooperativity; membrane remodeling; protei-lipid co-aggregation;

    Sammanfattning : α-synuclein is an intrinsically disordered protein implicated in synaptic vesicle trafficking at the synapse. Accumulation of α-synuclein in the form of amyloid deposits coincides with the loss of dopaminergic neurons in Parkinsons disease. LÄS MER

  4. 8. Equilibrium and Kinetic Studies of the Binding of DNA to Cationic Liposomes

    Författare :Paula Barreleiro; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Small-Angle Neutron Scattering; Fluorescence; Kinetics; Stopped-Flow; Differential Scanning Calorimetry; Titration Calorimetry; Gel-to-Liquid Crystalline Phase Transition; Lamellar phase; Lipolexes; DNA; Liposomes; Cryo-TEM; Physical chemistry; Fysikalisk kemi;

    Sammanfattning : The objective of this work was to study the formation of DNA-cationic vesicle complexes (lipoplexes). These complexes are interesting not only from a fundamental point of view but also as promising candidates for gene therapy. The approach taken was to study first the cationic vesicles by themselves. LÄS MER

  5. 9. Amyloid Proteins in Neurodegenerative Disease – Role of Extrinsic Modifiers

    Författare :Nima Sasanian; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : ABSTRACT Self-assembly of disease-associated proteins into fibrillar homopolymers, so-called “amyloid fibrils” is a pathological hallmark of several debilitating human disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). AD and PD are associated with the formation of amyloid fibrils from the proteins amyloid-β (Aβ) and α-syn (α-syn), in the extracellular and intracellular space, respectively. LÄS MER

  7. 10. Formation of Block Copolymer and Surfactant Vesicles

    Författare :Karin Bryskhe; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polymerteknik; Fysikalisk kemi; biopolymers; Polymer technology; nanoparticles; Lipid; triblock copolymer; surfactants; Nonionic; Vesicles; Formation; Physical chemistry;

    Sammanfattning : In this thesis temperature induced vesicle formation in both a block copolymer system and nonionic surfactant system have been investigated. The block copolymer is a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), PEO-PPO-PEO, with the average molecular composition of EO5PO68EO5 and the commercial trade name Pluronic L121 (papers I, II). LÄS MER