Sökning: "tumour stroma"

Visar resultat 11 - 15 av 34 avhandlingar innehållade orden tumour stroma.

  1. 11. Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour

    Författare :Daniel Sehic; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms Tumour; Nephroblastoma; SIX1; Blastema; biomarker; Immunochemisty; Immunohistochemestry;

    Sammanfattning : The aim of this thesis has been to establish biomarkers for the blastemal element in Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative chemotherapy are classified as high risk tumours. LÄS MER

  3. 12. Tumour microenvironment in serous ovarian cancer

    Författare :Sara Corvigno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ovarian cancer is the seventh most common malignancy in women worldwide and the most lethal gynaecological malignancy in developed countries. The epithelial subtype is divided in five main histologic groups, of which the high-grade serous is the most common subtype. LÄS MER

  4. 13. Pancreatic cancer – Influence of Tumour Microenvironment

    Författare :Chinmay Gundewar; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Pancreatic cancer (PC) is the fourth leading cause of cancer-related deaths, with a 5-year survival less than 6%. It does not show any symptoms in its early stages, hence most (>85%) of the patients are diagnosed at late stage. LÄS MER

  5. 14. Investigation of tumour/stroma crosstalk in pancreatic cancer by an advanced 3D co-culture model

    Författare :Xinyuan Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies all over the world. This dire situation is mainly attributable to the dense desmoplasia in the tumour microenvironment (TME) and almost complete resistance to conventional chemotherapy. LÄS MER

  7. 15. Investigations of Proneural Glioblastoma to Identify Novel Therapeutic Targets

    Författare :Maria Boije; Lene Uhrbom; Bengt Westermark; Rolf Bjerkvig; Uppsala universitet; []
    Nyckelord :Glioma; proneural subtype; hallmarks; glioma initiating cells; S-SOX5; angiogenesis; stromal cells; Tumour biology; Tumörbiologi; Experimentell patologi; Experimental Pathology;

    Sammanfattning : Malignant glioma is a highly lethal and destructive disease with no proper cure. We have investigated some of the hallmarks of cancer in connection to glioma and found ways to disrupt these and prevent tumor growth. The work is done within the context of a glioma subtype distinguished by activation of PDGF signaling termed the proneural subtype. LÄS MER