Avancerad sökning

Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Sulphonamide Resistance in Neisseria meningitidis and Commensal Neisseria Species

    Författare :Yvonne Qvarnström; Göte Swedberg; Dan Andersson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; sulphonamide resistance; Neisseria; natural transformation; adaptive evolution; substrate channelling; Mikrobiologi; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar;

    Sammanfattning : Extensive use of the sulphonamide drugs against the bacterium Neisseria meningitidis has resulted in drug resistance development. Sulphonamide resistance in N. meningitidis is caused by alterations in the chromosomal folP gene, coding for DHPS (dihydropteroate synthase). LÄS MER

  3. 2. Molecular basis for trimethoprim and sulphonamide resistance in Gram negative pathogens

    Författare :Malin Grape; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Resistance to antibiotics is becoming an important global public health problem. Infectious diseases are still among the major causes of disease and death in many parts of the world and the possibilities to treat bacterial infections are now threatened due to the spread of antibiotic resistance. LÄS MER

  4. 3. Fluoroquinolone resistance in the environment and the human gut – Analysis of bacterial DNA sequences to explore the underlying genetic mechanisms

    Författare :Anna Johnning; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antimicrobial resistance; Quinolones; Pollution; Next generation sequencing; Bioinformatics; Next generation sequencing;

    Sammanfattning : Fluoroquinolones (FQs) are synthetic, broad-spectrum antibiotics that target type II topoisomerases. High-level resistance is often caused by mutations in the target genes of FQs, especially in gyrA and parC. In contrast, plasmid-mediated resistance genes, such as qnr, often confer moderate levels of resistance. LÄS MER

  5. 4. Antibiotic Resistance and Fitness of Escherichia coli in the Infantile Commensal Microbiota

    Författare :Nahid Karami; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ampicillin; tetracycline; in vivo fitness; persistence; gene transfer; intestinal; blaTEM Escherichia coli;

    Sammanfattning : Microbial resistance to antibiotics is a growing problem worldwide. Resistance develops not only in microbes which are the targets of the antibiotic treatment, but also in those belonging to the normal microbiota of the treated host. Little is known on the ecological consequences of antibiotic resistance in commensal bacteria. LÄS MER

  7. 5. Antibiotic use and resistance : assessing and improving utilisation and provision of antibiotics and other drugs in Vietnam

    Författare :Mattias Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Antibiotic use; antibiotic resistance; private pharmacies; case management; knowledge; practice; interventions; enforcement of regulation; education; peer influence;

    Sammanfattning : Background: In Vietnam there were shortages of drugs until the end of the 1980's. In 1986 the "Doi Moi" economic reforms towards market economy were initiated. An expanding private health care sector emerged and the per capita drug consumption has increased dramatically. LÄS MER