Sökning: "stop codon"
Visar resultat 1 - 5 av 35 avhandlingar innehållade orden stop codon.
1. Evolutionary Mechanisms Shaping Bacterial Translation Termination
Sammanfattning : Translation termination in bacteria involves precise reading of stop codons (UAA, UAG, UGA) and coordinated peptidyl-tRNA hydrolysis by the class-I release factors (RFs) on the ribosome (70S). This thesis investigates the evolutionary and post-translational modification mechanisms of these RFs and the concurrent effect on bacterial translation termination. LÄS MER
2. From Structure to Function with Binding Free Energy Calculations for Codon Reading, Riboswitches and Lectins
Sammanfattning : Molecular association is part of many important processes in living cells. Computational methods for calculating binding free energies allows for a quantitative examination of biomolecular structures and hypotheses drawn from biochemical experiments. LÄS MER
3. Computational Studies of Protein Synthesis on the Ribosome and Ligand Binding to Riboswitches
Sammanfattning : The ribosome is a macromolecular machine that produces proteins in all kingdoms of life. The proteins, in turn, control the biochemical processes within the cell. It is thus of extreme importance that the machine that makes the proteins works with high precision. LÄS MER
4. Computational Analysis of Molecular Recognition Involving the Ribosome and a Voltage Gated K+ Channel
Sammanfattning : Over the last few decades, computer simulation techniques have been established as an essential tool for understanding biochemical processes. This thesis deals mainly with the application of free energy calculations to ribosomal complexes and a cardiac ion channel. LÄS MER
5. The Mechanism of translation termination in Escherichia coli
Sammanfattning : Protein synthesis in E. coli is terminated by the release factors (RFs) and the ribosome is prepared for another round of protein synthesis by ribosome recycling factor (RRF), elongation factor G (EF-G) and initiation factor (IF3). LÄS MER
