Sökning: "retinol"

Visar resultat 16 - 20 av 59 avhandlingar innehållade ordet retinol.

  1. 16. Retinoid metabolism and signalling in vascular smooth muscle cells

    Författare :Pauline Ocaya; Allan Sirsjö; Andreas C. Gidlöf; William S. Blaner; Örebro universitet; []
    Nyckelord :all-trans Retinol; all-trans Retinoic acid; retinoid metabolism; proliferation; Vascular smooth muscle cells; CYP26; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

    Sammanfattning : Smooth muscle cells (SMCs) play a major role in cardiovascular diseases. In advanced atherosclerosis, blood flow is impaired due to reduced luminal diameter. Percutaneous vascular interventions, including balloon angioplasty and stent-application are commonly used for the re-establishment of luminal size and improvement of tissue perfusion. LÄS MER

  3. 17. Effects of prolactin on metabolism - changes induced by hyperprolactinemia

    Författare :Louise Nilsson; Göteborgs universitet; []
    Nyckelord :prolactin; prolactin receptor; hyperprolactinemia; adipose tissue; lipoprotein lipase; malonyl-CoA; glucose transporter 4; retinol-binding protein 4; adiponectin; lipid oxidation;

    Sammanfattning : High prolactin levels during breast-feeding, is recognized to influence metabolism in order to supply glucose and fat for milk production. Pathologic overproduction of prolactin, hyperprolactinemia, is a condition primarily associated with reproductive disorders; however, the metabolic impact of elevated prolactin indicates that these parameters might be considered in clinical management of the condition. LÄS MER

  4. 18. Disruption of vitamin A metabolism by dioxin

    Författare :Pi Högberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TCDD; dioxin; vitamin A; retinoic acid; cellular retinol-binding protein; bone;

    Sammanfattning : Vitamin A (retinoids) is a nutrient that plays a central role in development and remains essential for cell growth and differentiation throughout life. Dioxins are polychlorinated organic pollutants known to negatively affect the storage and body clearance of retinoids. LÄS MER

  5. 19. Studies on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A homeostasis

    Författare :Charlotte Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TCDD; dioxin; vitamin A; retinoic acid; lecithin:retinol acyltransferase; retinyl ester hydrolysis; retinol-binding protein; kidney; lymph; stellate cell; kinetics; model-based compartmental analysis;

    Sammanfattning : Vitamin A (retinoids) is needed for normal vision, growth, reproduction, cell differentiation, embryonic development, and immune function. Retinoids exert their functions in the same way as classical hormones, as transcription factors acting via nuclear receptors. LÄS MER

  7. 20. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A storage in rat hepatic stellate cells

    Författare :Annika Hanberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dioxin; TCDD; vitamin A; retinoids; lecithin:retinol acyltransferase; absorption; stellate celL hepatic vitamin A accumulation; intestinal lymph collectionDoctoral Thesis 1996 Annika Hanberg;

    Sammanfattning : The polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), popularly called dioxins, are persistent pollutants with widespread occurrence in the environment as well as in human food and tissues. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin, as well as other dioxin-like compounds induce a broad spectrum of biochemical and toxic effects, many of which occur at extremely low doses or concentrations. LÄS MER