Sökning: "paraskevi heldin"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden paraskevi heldin.

  1. 1. Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer

    Författare :Merima Mehić; Paraskevi Heldin; Carl-Henrik Heldin; Liliana Schaefer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; TGFβ; PDGF-BB; cancer; signaling; hyaluronan synthase; epithelial-mesenchymal transition; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface receptor CD44, is involved in intracellular signaling pathways regulating major cellular processes during development, wound healing, inflammation and cancer. LÄS MER

  3. 2. Studies on the phosphorylation of fibrinogen

    Författare :Paraskevi Heldin; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 3. Importance of Hyaluronan Metabolism and Signalling in Tumour Progression

    Författare :Berit Bernert; Paraskevi Heldin; Peter Prehm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; cancer; growth factors;

    Sammanfattning : Hyaluronan, an unbranched glycosaminoglycan of the extracellular matrix, has an amazingly simple structure. Initially thought to fulfil only hydrating and space-filling functions in tissues, evidence generated during the past decades shows that hyaluronan is involved in intriguingly complex signalling events in health and disease. LÄS MER

  5. 4. Effect of Hyaluronan-activation of CD44 on Cell Signaling and Tumorigenesis

    Författare :Lingli Li; Paraskevi Heldin; Raija H. Tammi; Uppsala universitet; []
    Nyckelord :Biomedicine; Hyaluronan; CD44; growth factors; chemokines; tumorigenesis; wound healing; cell signaling; Biomedicin;

    Sammanfattning : Hyaluronan (HA), a structural component in the extracellular matrix (ECM), has been recognized as a signaling molecule. It is important during various biological activities such as embryogenesis, angiogenesis, wound healing and tumor progression. LÄS MER

  7. 5. The role of hyaluronan and its CD44 receptor in inflammation and cancer

    Författare :Chun-Yu Lin; Jyrki Tenhunen; Miklós Lipcsey; Paraskevi Heldin; Markku Tammi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD44; Dengue; Hyaluronan; HAS2; iASPP; TGFbeta; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Hyaluronan, an important extra-cellular matrix molecule, was thought to be interstitial connecting glue decades ago. However, recent evidence has revealed that hyaluronan and its binding proteins also play crucial roles in various pathophysiological conditions in humans, including inflammation and infection. LÄS MER