Sökning: "oxaliplatin"

Visar resultat 6 - 10 av 29 avhandlingar innehållade ordet oxaliplatin.

  1. 6. Cationic Interactions with Nucleic Acids With Focus on Anticancer Active Platinum(II) Complexes

    Författare :Åse Sykfont Snygg; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; in-line cleavage; Cisplatin; oxaliplatin; circular dichroism; DENSPM; polyamines; siRNA; pseudoknot; RNA; thermal melting; anticancer active Pt II complex; DNA;

    Sammanfattning : It is well documented that the antitumour activity of the Pt(II)-complex cisplatin, and similar anticancer active complexes, is a result of metalation of DNA, and thereby inhibition of cell proliferation. Since nucleic acids are polyanions at physiological pH, the rate of adduct formation with positively charged complex, as the hydrolyzed Pt(II) complexes studied in this work, is influenced by the ionic environment surrounding the polymer. LÄS MER

  3. 7. Chemical transformation of the anticancer drug oxaliplatin

    Författare :Elin Jerremalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxaliplatin is a new platinum based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin, both as palliative and adjuvant treatment of metastatic colorectal cancer. Various biotransformation products are formed non-enzymatically after oxaliplatin administration. LÄS MER

  4. 8. Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects

    Författare :Elin Jerremalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxaliplatin is a platinum-based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin for palliative and adjuvant treatment of metastatic colorectal cancer. LÄS MER

  5. 9. Chemical, pharmacokinetic and biological aspects of platinum-based drugs

    Författare :Jeffrey R Yachnin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The use of cisplatin for the treatment of metastatic testicular cancer is a medical historical landmark given that, for the first time, patients could be cured with drug therapy. A third generation platinum-based drug, oxaliplatin, has been registered for use in the treatment of colorectal cancer. LÄS MER

  7. 10. Pharmacokinetics and inner ear transport of cisplatin

    Författare :Victoria Hellberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Cisplatin is a commonly used platinum anti-cancer drug. Regrettably cisplatin has dose-limiting ototoxic side effects, e.g. the drug can induce an irreversible hearing loss. LÄS MER