Sökning: "neuronal integrity"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden neuronal integrity.

  1. 1. The search for reversibility of Idiopathic normal pressure hydrocephalus : Aspects on intracranial pressure measurments and CSF volume alteration

    Författare :Niklas Lenfeldt; Jan Malm; Anders Eklund; Katrine Riklund-Åhlström; John D. Pickard; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Idiopathic normal pressure hydrocephalus; intracranial pressure; subcortical ischemia; neuronal integrity; cortical activation.; infusion test; cerebrospinal fluid dynamics; outflow resistance; compliance; elastance; proton spectroscopy; functional MRI; external lumbar drainage; Neurology; Neurologi;

    Sammanfattning : BACKGROUND: Idiopathic normal pressure hydrocephalus (INPH) is still a syndrome generating more questions than answers. Today, research focuses mainly on two areas: understanding the pathophysiology – especially how the malfunctioning CSF system affects the brain parenchyma – and finding better methods to select patients benefiting from a shunt operation. LÄS MER

  3. 2. Ischemic and Hypoglycemic Brain Damage, Involvement of the Mitochondrial Permeability Transition Pore

    Författare :Hans Friberg; Lund Wallenberg Neurocentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitochondrial permeability transition pore; mitochondria; apoptosis; neuronal death; brain; ischemia; hypoglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Brain damage from ischemia-reperfusion and hypoglycemia are major causes of morbidity and mortality. Therapeutic strategies include hypothermia, glutamate-receptor blockade, immunosuppression and lately treatment aiming at preserving mitochondrial integrity and function. LÄS MER

  4. 3. Neurobiological markers for personality, inflammation and stress: A naturalistic study in knee arthroplastic patients

    Författare :Sara Bromander; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; personality; cytokine; aggression; inflammation; impulsivity; inslulin; blood-brain barrier;

    Sammanfattning : Background: Psychiatry has strived to identify biomarkers elucidating the underlying biological mechanisms behind different disorders, to help in diagnostics and to assess treatment effects. In forensic psychiatric populations, findings have connected levels of cerebrospinal fluid (CSF) monoamine metabolites and blood-brain barrier (BBB) integrity with impulsivity and aggression. LÄS MER

  5. 4. Single cell analysis of iPS derived neural stem cells and neurons

    Författare :Matti Lam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In vitro derived neural stem cells can be used to model events of neurogenesis and neurodevelopmental dysfunction. Formation of stable neural stem cell environments relies on cellular components to stabilize cell-to-cell connections. LÄS MER

  7. 5. The functional impact of gut microbiota on CNS regulation of local and systemic homeostasis

    Författare :Afrouz Abbaspour; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The “gut microbiota” is widely accepted as an integral part of the gut homeostasis, and is thought to contribute to the establishment of intestinal barrier. Growing body of research suggest that the influence of gut microbiota on host development and physiology reaches beyond the gastrointestinal tract, and the brain is not an exception. LÄS MER