Sökning: "liver regeneration"

Visar resultat 11 - 15 av 26 avhandlingar innehållade orden liver regeneration.

  1. 11. Experimental and clinical studies on liver regeneration and hepatocellular carcinoma : roles of redox proteins, iron homeostasis and multikinase inhibition

    Författare :Annelie Mollbrink; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Compensatory liver regeneration is triggered by chronic liver injury or surgery and is crucial to maintain tissue homeostasis. The underlying mechanisms which include a whole battery of complex signaling events have been thoroughly studied for decades. LÄS MER

  3. 12. Experimental studies on the effects of hepatocyte-based liver support

    Författare :Helene Lilja; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : Liver transplantation is limited by lack of donors and consequently there is a need to develop liver support/replacement therapies, such as hepatocyte transplantation (HcTx) and artificial livers. In the present thesis, the effects of these therapies were investigated. First, we established a technique of isolating fetal hepatocytes (FH). LÄS MER

  4. 13. Biocatalysed redox reactions in aqueous and organic media

    Författare :Mats Andersson; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; PLS; coenzyme regeneration; bioelectrocatalysis; hydrogenase; chloroperoxidase; HLADH; Proteus vulgaris; Alcaligenes eutrophus; artificial electron mediator; D- S _chlorolactic acid; Biotechnology; Bioteknik;

    Sammanfattning : This thesis deals mainly with biocatalysed methods for stereoselective reduction. D-(S)-chlorolactic acid was produced by both microbial and electromicrobial reduction of chloropyruvate using whole cells of Proteus vulgaris and an artificial electron mediator. The electron donor was formate, hydrogen gas or the cathode in an electrochemical cell. LÄS MER

  5. 14. A fishing expedition for antidiabetic drugs : identifying new avenues to stimulate beta-cell regeneration

    Författare :Christos Karampelias; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : All types of diabetes are characterized by loss of the insulin-producing β-cells that reside in the pancreas. While current treatments can manage the disease, there is still no cure available. Understanding and promoting endogenous β-cell regeneration is an attractive approach that can lead to an eventual cure for diabetes. LÄS MER

  7. 15. Lineage tracing of early organogenesis and liver mesenchymal cells with ultrasound-guided in utero nano-injection

    Författare :Jingyan He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Current methods used to investigate embryo development and alter gene expression in mouse embryos are often time consuming and require large numbers of mice. To circumvent these limitations, we were aiming to develop a flexible and efficient method to investigate embryo development and manipulate gene expression in utero. LÄS MER