Sökning: "liver endothelial cells"

Visar resultat 16 - 20 av 48 avhandlingar innehållade orden liver endothelial cells.

  1. 16. The importance of endothelin-1 for vascular function in patients with atherosclerosis and healthy controls

    Författare :Felix Böhm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acetylcholine; atherosclerosis; blood flow; circulation; coronary disease; endothelin; endothelium; kidney; liver; nitric oxide; patients; receptors; vasoconstriction.;

    Sammanfattning : Background: Atherosclerosis is associated with endothelial dysfunction, which is an early sign with prognostic implications in patients with coronary artery disease. Atherosclerosis is also associated with enhanced expression of the vasoconstrictor peptide endothelin-1 (ET-1). LÄS MER

  3. 17. Isolation and characterization of genes within the region for multiple endocrine neoplasia type 1 on chromosome 11q13

    Författare :Jacob Lagercrantz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multiple Endocrine Neoplasia type 1 MEN1 ; Chromosome 11q13; Phospholipase C Beta 3 gene PLCB3 ; Phospholipase C Beta 3 Neighbouring Gene PNG ; Vascular Endothelial Growth Factor VEGF ; VEGF Related Factor gene VRF .;

    Sammanfattning : This thesis summarizes the investigations of three genes isolated from the locus for multiple endocrine neoplasia type 1 (MEN1) within the chromosomal region 11q13. As a common strategy for all three genes, the cDNA was sequenced, the genomic structure characterized, and the expression pattern analyzed by Northern blotting on human tissues and by in situ RNA hybridization on slides from rodent embryos. LÄS MER

  4. 18. RP59 : a novel stem cell protein and mapping of its expression

    Författare :Anders Krüger-Almerén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The purpose of this thesis was to study the expression pattern of a novel protein daring developmental processes. Firstly we identified so far unknown mRNA sequences coding for frequently expressed proteins in primitive mesenchymal cells in bone marrow and osteoblasts. LÄS MER

  5. 19. The enzymatic machinery of leukotriene biosynthesis : Studies on ontogenic expression, interactions and function

    Författare :Tobias Strid; Sven Hammarström; Mats Söderström; Ralf Morgenstern; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Leukotrienes (LTs) are biologically active arachidonic acid (AA) derivatives generated by the 5-lipoxygenase (5-LO) pathway. They are produced by myeloid cells. 5-LO converts AA to LTA4 in cooperation with 5-LO activating protein (FLAP). LTA4 is converted to LTB4, by LTA4-hydrolase (LTA4H) or to LTC4 by LTC4-synthase (LTC4S). LÄS MER

  7. 20. The role of Shb in ES cell differentiation, angiogenesis and tumor growth

    Författare :Nina Funa; Michael Welsh; Leif Jansson; Lars Holmgren; Uppsala universitet; []
    Nyckelord :Cell biology; Shb; tyrosine kinase signaling; ES; endoderm; mesoderm; apoptosis; microvasculature; tumor growth; Cellbiologi;

    Sammanfattning : Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors and intracellular signaling proteins. Previous studies have implied a wide spectrum of Shb-mediated cellular responses, which motivated me to further investigate the role of Shb in differentiation and angiogenesis. LÄS MER