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1. 1. Cellular mechanisms involved in bone resorption

   Författare :Ulf Lerner; Umeå universitet; []
   Nyckelord :Bone resorption. cyclic AMP; parathyroid hormone; prostaglandins; la OH D3; lysosomal enzyme release; osteoclast; periodontitis; rheumatoid arthritis;

   Sammanfattning : The effects of parathyroid hormone (PTH), prostaglandins (PGE1, PGE2, PGF2a), cAMP, cAMP-analogues, phosphodiesterase (PDE) inhibitors and la (OH) D3 on bone resorption and associated cellular process have been studied in a bone organ culture system using half- calvaria from 6-7 day-old mice. Bone resorption was assessed by determining the release of calcium (Ca2+), inorganic phosphate (Pi) and 45Ca from the calvarial bones to the culture media. LÄS MER