Sökning: "khalili"

Visar resultat 11 - 13 av 13 avhandlingar innehållade ordet khalili.

  1. 11. Development of DNA-based methods for analysis of protein interactions

    Författare :Axel Klaesson; Ola Söderberg; Mats Nilsson; Cristina Al-Khalili Szigyarto; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; In situ proximity ligation assay PLA ; rolling circle amplification RCA ; Hybridization chain reaction HCR ; proxHCR; Oligonucleotide design; Protein-protein interactions; Post-translational modifications.; Farmaceutisk vetenskap; Pharmaceutical Science; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : In situ proximity ligation assay (PLA) is a method for detection of protein interactions, post-translational modifications (PTMs) and individual proteins that allows information about their localization in a cell or tissue to be extracted. The method is based on oligonucleotide-conjugated antibodies (proximity probes) that upon binding of two epitopes in close proximity give rise to an amplifiable DNA circle. LÄS MER

  3. 12. Analysis of PDGF receptor internalization and signaling using proximity ligation assays

    Författare :Marie Rubin Sander; Ola Söderberg; Cristina Al-Khalili Szigyarto; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGFRβ; dynamin; proteolytic cleavage; signaling; internalization; protein-protein interaction; short linear motif; viral hijack; in situ PLA; Molboolean;

    Sammanfattning : Cell signaling is mediated by signaling proteins that relay the signal in an intricate network of interactions before the signal is translated into a biological response. Short linear motifs (SLiMs) in intrinsically disordered regions of proteins serve as docking sites for protein interaction in all aspects of cell regulation including signal transduction. LÄS MER

  4. 13. Flourescence properties of trendy molecules studied with synchrotron radiation

    Författare :Gemma Vall-Llosera; Elisabeth Rachlew-Källne; Ahmed Al-Khalili; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physics; Fysik;

    Sammanfattning : This thesis summarises the experimental results on molecular spectroscopy of gas phase molecules using synchrotron radiation in the UV- VUV and soft-X rays regions. The results of applying Photon Induced Fluorescence Spectroscopy (PIFS) to D2, H2S, H2O and pyrimidine are presented and discussed. LÄS MER