Sökning: "isabelle"

Visar resultat 6 - 10 av 60 avhandlingar innehållade ordet isabelle.

  1. 6. CD8alpha/alpha+ T-cells and immune memory

    Författare :Isabelle Magalhaes; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A better understanding of T-cell memory formation is crucial for rationale vaccine design and the identification of correlates of immune protection. The CD8αα homodimer expressed on CD8+ T-cells is not anymore considered to represent a TCR co-receptor, it may rather represent a mechanism to modulate T-cell avidity and identify a subset of memory T-cells. LÄS MER

  3. 7. Developing trust among family owners in multiple branches family firms

    Författare :Isabelle Mari; Leif Melin; Mattias Nordqvist; Lloyd Steier; Jönköping University; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES;

    Sammanfattning : This dissertation studies trust in Multiple Branches Family Firms. It focuses on a form of trust that has received little attention: collective trust (Kramer 2010). LÄS MER

  4. 8. Recreating the microenvironment of the neurovascular unit

    Författare :Isabelle Matthiesen; Anna Herland; Thomas E. Winkler; Stéphanie Descroix; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microphysiological systems; neurovascular unit; induced pluripotent stem cells; extracellular matrix; hydrogels; in vitro models; mikrofysiologiska system; neurovaskulära enheten; inducerade pluripotenta stamceller; extracellulära matrisen; hydrogeler; in vitro modeller; Bioteknologi; Biotechnology;

    Sammanfattning : The neurovascular unit (NVU) comprises the blood-brain-barrier (BBB) and its surrounding astrocytes, pericytes and neurons that are embedded in the extracellular matrix (ECM). As the main function of the BBB is to protect the brain from inlet of pathogens and toxins, the specialized endothelial cells that keep the barrier tight will also hinder the passage of pharmaceuticals. LÄS MER

  5. 9. Pathways controlling metabolic and hypertrophic responses in skeletal muscle

    Författare :Isabelle Riedl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscle displays an extensive capacity to adapt to a wide range of metabolic and mechanical stressors. As an insulin-sensitive and exercise-responding tissue, it plays a key role in the context of therapeutic interventions targeting metabolic diseases including type 2 diabetes (T2D) and obesity. LÄS MER

  7. 10. Novel aspects of neuroblastoma : to hypoxia and beyond

    Författare :Isabelle Westerlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma (NB) is a pediatric cancer arising from the neural crest cells forming the sympathetic nervous system. Just as other types of pediatric cancer the driving mutations of neuroblastoma are few and the tumors are instead categorized according to genetic abbreviations such as amplification, loss of heterozygosity, gains and translocations. LÄS MER