Sökning: "immunoregulation"

Visar resultat 21 - 25 av 25 avhandlingar innehållade ordet immunoregulation.

  1. 21. Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice

    Författare :Simon Guérard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and eventually invalidity if left untreated. LÄS MER

  3. 22. Natural killer cell tolerance : influence of the MHC class I expression in the host

    Författare :Maria H Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; MHC class 1; tolerance; transgenic mice; Ly49;

    Sammanfattning : Development of self-tolerance in the immune system is characterized by somatic processes aiming at permanently eliminating, or silencing, potentially autoreactive lymphocytes. Such tolerance mechanisms are of outmost importance if autoimmunity is to be avoided. LÄS MER

  4. 23. Genetic polymorphism and natural killer cell activity in multiple myeloma

    Författare :Chengyun Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple Myeloma (MM) is a B cell malignancy characterised by an accumulation of clonal neoplastic plasma cells in bone marrow. Its aetiology remains unknown. Remarkable racial differences in the incidence of MM and occurrence of familial MM suggest that genetic factors may play a role in the development of MM. LÄS MER

  5. 24. Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in G?i2-deficient and DSS-induced Colitis as well as in IBD patients

    Författare :Kristina Elgbratt; Göteborgs universitet; []
    Nyckelord :Inflammatory bowel diseaseInflammatory bowel disease; G?i2- - mice; dextran sodium sulfate; thymocytes; T cell receptor excision circles TRECs ; resent thymic emigrants;

    Sammanfattning : Characteristics and Consequences of Thymic Involution in Inflammatory Bowel Disease. Experimental studies in G?i2-deficient and DSS-induced Colitis as well as in IBD patients Kristina Elgbratt Department of Microbiology and Immunology, Institute of Biomedicine, The Sahlgrenska Academy, G?teborg University, G?teborg Sweden Inflammatory Bowel Disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract, comprising ulcerative colitis and Crohn?s disease. LÄS MER

  7. 25. Interventional studies on immunological balance in IBD and allergic asthma

    Författare :Vladislaw Muratov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : We have studied a role of immunological balance in connection to allergen challenge in asthma patients and in connection to apheresis treatment in inflammatory bowel disease (IBD) patients. It has been suggested that T-helper type 2 cells become recruited into the bronchial mucosa and regulate allergic asthma reaction. LÄS MER