Sökning: "G?i2- - mice"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden G?i2- - mice.
1. Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis
Sammanfattning : The overall aim of this thesis was to increase the understanding of the immunopathology of Inflammatory Bowel Disease (IBD). The first aim was to elucidate how the thymus and the gut epithelium were affected by colitis. The second aim was to investigate new ways of assessing and monitoring colitis. LÄS MER
2. Intracellular regulation of TLR signaling Basic mechanisms and importance in intestinal inflammation
Sammanfattning : Toll-like receptors (TLRs) recognize conserved structures on/in microorganisms. The intracellular signalling pathways of TLRs are shared with IL-1R and IL-18R and their activation leads to transcription of proinflammatory cytokines and type-I interferons. LÄS MER
3. Immunopathogenesis of Gai2-deficient mice. A model of inflammatory bowel disease
Sammanfattning : The intestinal mucosa is the largest lymphoid organ in the body, and it simultaneously has to protect us from any pathogen that might enter the gastrointestinal tract as well as maintaining tolerance to most antigens, mainly in the form of dietary constituents and microbial products. A dysfunctional control of local intestinal immune responses may lead to development of Inflammatory Bowel Disease (IBD) - the common name for ulcerative colitis (UC) and Crohn´s disease (CD). LÄS MER
4. Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis
Sammanfattning : The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory G protein subunit Gαi2 spontaneously develop chronic colitis and have been used as a model for IBD, with particular similarities to UC. LÄS MER
5. Zonal organization of the mouse olfactory systems
Sammanfattning : Animals survey their environment for relevant odorous chemical compounds by means of the olfactory system. This system is in most vertebrates divided into a main and accessory olfactory system with two specialized neuroepithelia, the olfactory and the vomeronasal epithelium, respectively. LÄS MER