Sökning: "hypermutation"

Visar resultat 16 - 20 av 23 avhandlingar innehållade ordet hypermutation.

  1. 16. Repertoire diversity and maturation of HIV-1 vaccine-induced B cell responses

    Författare :Ganesh Eknath Phad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the work presented in this thesis, I characterized B cell responses in rhesus macaques inoculated with HIV-1 envelope glycoprotein (Env)-based vaccines to define genetic and functional properties of the elicited antibodies for an improved understanding of Env immunogenicity. In Paper I, we investigated antibody heavy chain V gene segment expression in the overall B cell repertoire and in response to vaccination by using 2 approaches, 454-pyrosequencing and single-cell RT-PCR of bulk and sorted memory B cells, respectively. LÄS MER

  3. 17. Dissection of HIV-1 Env-specific B cell responses in nonhuman primates

    Författare :Christopher Sundling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Vaccine-induced protection is generally mediated by long-lived antigen-specific B cell responses. Most licensed vaccines target pathogens that display relatively low variability, but for highly variable pathogens, such as HIV-1, vaccine development is more challenging. LÄS MER

  4. 18. Characterization of the genome and tumor microenvironment of human B-cell lymphoma

    Författare :Xiaofei Ye; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Non-Hodgkin lymphoma (NHL) is the 13th most common type of cancer worldwide in 2020 and consists mainly of human B-cell lymphoma (approximately 85%). Diffuse large B-cell lymphoma (DLBCL) is the most common NHL subtype (approximately 30%). LÄS MER

  5. 19. Immunoglobulin gene usage and affinity maturation in antiviral antibodies

    Författare :Pradeepa Pushparaj; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ability of antibodies to block infections makes them highly relevant for successful vaccine development. Through the papers described in this thesis, I attempt to characterize the functional and genetic aspects of antiviral antibodies induced by infection and vaccination. LÄS MER

  7. 20. Impairment of B cell trafficking and differentiation during HIV-1 infection

    Författare :Vu Phuong Linh Dang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the course of HIV-1 infection, several B cell dysfunctions occur as result of virus replication and indirect mechanisms of immunopathology. The B cells abnormalities include hypergammaglobulinemia, a decreased number of memory B cells, increased levels of activation markers on B cell surface and plasmacytosis. LÄS MER