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Visar resultat 1 - 5 av 11 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Functional brain activity in Alzheimer patients as studied by multi-tracer positron emission tomography : effects of treatment with cholinesterase inhibitors

    Författare :Ahmadul Kadir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer’s disease; cholinesterase inhibitors; positron emission tomography; nicotinic acetylcholine receptor; acetylcholinesterase; multi-tracer; 11C-nicotine; 11C-PMP; 18F-FDG; 11C-PIB; donepezil; rivastigmine; galantamine; phenserine.;

    Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disease accompanied by cognitive impairment and disturbances in several neurotransmitter systems, especially the cholinergic system. Studies have correlated the cognitive impairment observed in AD patients with a deficit in central cholinergic neurotransmission. LÄS MER

  3. 2. Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease

    Författare :Marie M Svedberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD) is the most frequent type of dementia and is characterized neuropathologically by deposition of plaques containing beta-amyloid (Abeta) and by neurofibrillary tangles, of which the main component is hyperphosphorylated tau. The degenerative progression seen in AD is accompanied by disturbances in several neurotransmitter systems, especially the cholinergic neurotransmitter system. LÄS MER

  4. 3. Long Term Outcome and Prediction Models of Cognition, Activities of Daily Living and Nursing Home Placement in Alzheimer’s Disease with Cholinesterase Inhibitor Treatment

    Författare :Carina Wattmo; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; longitudinal studies; nursing home placement; activities of daily living; cognition; Alzheimer s disease; cholinesterase inhibitors; disease progression; predictors; statistical models.;

    Sammanfattning : Background Prospective longitudinal studies in Alzheimer's disease (AD) that include cholinesterase inhibitor (ChEI) treatment in routine clinical settings are scarce. The patients vary in severity of the disease, clinical course, rate of progression and response to treatment. LÄS MER

  5. 4. Using CSF biomarkers to understand mechanisms of behavioral changes and effects of drug treatment in dementia

    Författare :Victor Bloniecki Kallio; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dementia is affecting millions of people around the world, and the global prevalence will continuously rise. Neuropsychiatric symptoms (NPS) in dementia are frequent and constitute a key driving force in the disease burden for both patients, families, caregivers and society. LÄS MER

  7. 5. Novel pharmacological treatment alternatives for schizophrenia

    Författare :Charlotte Wiker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antipsychotic drugs are commonly divided into typical (first generation) and atypical (second generation) antipsychotic drugs. Clinically effective doses of typical antipsychotic drugs generate a striatal dopamine D2 receptor occupancy of about 70 80%, approaching a level that is associated with a high risk of extrapyramidal side effects. LÄS MER