Sökning: "duration of disease onset"

Visar resultat 21 - 25 av 88 avhandlingar innehållade orden duration of disease onset.

  1. 21. Congenital Heart Disease, Type 1 and Type 2 Diabetes Mellitus

    Författare :Anna Björk; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Congenital Heart Disease; Diabetes Mellitus; Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus; Mortality; Morbidity;

    Sammanfattning : Worldwide, 1% of all live born children are born with a congenital heart disease (CHD) and currently >95% reach adulthood due to better diagnostics and medical care. At the same time, Diabetes Mellitus (DM), type 1 (T1DM) and type 2 (T2DM), is increasing worldwide. LÄS MER

  3. 22. Pharmacodynamic Modelling of Irreversible and Reversible Gastric Proton Pump Inhibitors

    Författare :Angela Äbelö; Mats Karlsson; Michael Looby; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Sammanfattning : Acid related diseases like GERD, duodenal-and gastric ulcers and H. Pylori-positive peptic ulcer disease are primarily managed by reducing gastric acidity. Irreversible proton pump inhibitors (PPIs) inhibit gastric acid secretion effectively throughout the day by irreversibly inhibiting the gastric proton pump, H+, K+-ATPase, in the parietal cells. LÄS MER

  4. 23. Natural history of Alzheimer's disease and other dementias : findings from a population survey

    Författare :Hedda Aguero-Eklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this doctoral thesis is to increase understanding of the natural history of different types of dementia in a very old population. Five studies were performed using data from the Kungsholmen Project, a population-based study on aging and dementia in Stockholm that includes subjects aged 75+. LÄS MER

  5. 24. Methodological aspects and usefulness of Quantitative Sensory Testing in early small fiber polyneuropathy : a clinical study in Swedish hereditary transthyretin amyloidosis patients

    Författare :Victoria Heldestad; Erik Nordh; Ole Suhr; Göran Solders; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloidosis; cold thresholds; heart rate variability; method-of-limits; quantitative sensory testing; transthyretine; warm thresholds; Clinical Neurophysiology; klinisk neurofysiologi;

    Sammanfattning : Generalised polyneuropathy (PNP) is a common cause to neurological impairment, and may be an early symptom of a severe systemic disease. One such illness is hereditary transthyretin (TTR) amyloidosis (ATTR), a progressive fatal disorder caused by a mutation on the TTR gene. LÄS MER

  7. 25. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies

    Författare :Manuela Lehmann; Jonathan D. Gilthorpe; Stefan L. Marklund; Thomas Brännström; Ulrika Nordström; Elizabeth Fisher; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; antibodies; SOD1; disordered SOD1; patient-derived models; low oxygen tension; Immunotherapy;

    Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER