Sökning: "dasatinib"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet dasatinib.

  1. 1. Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia

    Författare :Sofia Jönsson; Göteborgs universitet; []
    Nyckelord :Chronic myeloid leukemia; tyrosine kinase inhibitor; imatinib; molecular response; adherence; mesechymal stem cells; osteoblast differentiation; dasatinib;

    Sammanfattning : Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. Currently, there are three TKIs approved for treatment of CML, imatinib, nilotinib and dasatinib. LÄS MER

  3. 2. Clinical and Genetic studies in Chronic Myeloid Leukaemia

    Författare :Hjalmar Flygt; Ulla Olsson Strömberg; Stina Söderlund; Lucia Cavelier; Jane Apperley; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; Chronic Myeloid Leukemia; Medicinsk vetenskap; Medical Science;

    Sammanfattning : This thesis explores strategies to enhance deep molecular response (DMR) rates and treatment-free remission (TFR) eligibility in chronic myeloid leukaemia (CML), investigates factors linked to treatment milestone failures, describes tyrosine kinase inhibitor (TKI) discontinuation outcomes in a population-based cohort, and examines TFR probabilities after a second TKI discontinuation. In paper I we examined data from the Swedish CML registry on 128 CML patients in chronic phase with a reported TKI discontinuation of ≥1 month due to DMR. LÄS MER

  4. 3. Dissolving the Rocks : Solubility Enhancement of Active Pharmaceutical Ingredients using Mesoporous Silica

    Författare :Xin Xia; Alfonso E. Garcia-Bennett; Xiaodong Zou; Göran Frenning; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mesoporous silica; drug delivery; solubility enhancement; active pharmaceutical ingredients; oral toxicity; confinement; crystallization; pharmaceutical excipients; bioavailability; Inorganic Chemistry; oorganisk kemi;

    Sammanfattning : Poor aqueous solubility is one of the greatest barriers for new drug candidates to enter toxicology studies, let alone clinical trials. This thesis focuses on contributing to solving this problem, evaluating the oral toxicity of mesoporous silica particles, and enhancing the apparent solubility and bioavailability of active pharmaceutical ingredients in vitro and in vivo using mesoporous silica particles. LÄS MER

  5. 4. Mesoporous Silica SBA-15 - Formation, Modification and Application

    Författare :Tomas Kjellman; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SBA-15; Mesoporous Silica; Intrawall pores; Colloidal Stability; Drug release; Deposition;

    Sammanfattning : Several aspects related to the mesoporous silica material SBA-15 have been studied through the use of a wide range of experimental techniques, including low voltage high-resolution scanning electron microscopy, small angle X-ray scattering and nitrogen sorption. This work contains three parts, which are in many ways overlapping. LÄS MER

  7. 5. Influence of CYP3A enzymes and ABC transporters on the activity of tyrosine kinase inhibitors in chronic myeloid leukemia

    Författare :Karin Skoglund; Henrik Gréen; Curt Peterson; Kourosh Lotfi; Staffan Hägg; Jörg Cammenga; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : The introduction of imatinib, a tyrosine kinase inhibitor (TKI), in the treatment of chronic myeloid leukemia (CML) was a major break-through and the first drug that was successfully designed to target the specific mechanism of a malignant disease. Imatinib still remains as the standard treatment of newly diagnosed CML patients although a second generation of TKIs has also been approved for first-line CML treatment. LÄS MER