Sökning: "osteoblast differentiation"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden osteoblast differentiation.

  1. 1. CD47–SIRPα : an interaction of importance for bone cell differentiation

    Författare :Cecilia Koskinen; Pernilla Lundberg; Per-Arne Oldenborg; Riku Kiviranta; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; SIRPalpha; osteoblast; osteoclast; SHP-2; Akt2; cell research; cellforskning;

    Sammanfattning : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. LÄS MER

  3. 2. Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia

    Författare :Sofia Jönsson; Göteborgs universitet; []
    Nyckelord :Chronic myeloid leukemia; tyrosine kinase inhibitor; imatinib; molecular response; adherence; mesechymal stem cells; osteoblast differentiation; dasatinib;

    Sammanfattning : Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. Currently, there are three TKIs approved for treatment of CML, imatinib, nilotinib and dasatinib. LÄS MER

  4. 3. miRNA and Asymmetric siRNA : Small RNAs with Large Effects on Bone Metabolism

    Författare :Navya Laxman; Andreas Kindmark; Sara Windahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miRNA; cp-siRNA; RNAi; bone; Osteoblast; Sequencing; Differential expression; Wnt pathway; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : RNA interference (RNAi) is a post-transcriptional gene silencing process elicited by double-stranded RNA, such as micro-RNA (miRNA) and small interfering RNA (siRNA). They are 18-25 nucleotide long, small non-coding RNAs acting as critical regulators in eukaryotic genome expression. LÄS MER

  5. 4. The biological and physical performance of high strength dicalcium phosphate cement in physiologically relevant models

    Författare :Michael Pujari-Palmer; Håkan Engqvist; Marjam Karlsson Ott; Christele Combes; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biomaterial; bioceramic; osteoinduction; calcium phosphate; cement; osteoblast; pyrophosphate; Rebamipide; drug delivery; screw augmentation; Teknisk fysik med inriktning mot materialvetenskap; Engineering Science with specialization in Materials Science;

    Sammanfattning : The chemical properties of calcium phosphate cements (CPCs) are very similar to the mineral phase of bone. CPCs are, consequently, very effective substrates (scaffolds) for tissue engineering; bone and stem cells attach readily, and can proliferate and differentiate to form new bone tissue. LÄS MER

  7. 5. The neuropeptide VIP and the IL-6 family of cytokines in bone : effects on bone resorption, cytokine expression and receptor signalling in osteoblasts and bone marrow stromal cells

    Författare :Emma Persson; Ulf Lerner; Andreas Kindmark; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; osteoblast; bone resorption; cytokines; IL-6; neuropeptides; VIP; transcription factor; Cell biology; Cellbiologi;

    Sammanfattning : Bone tissue is continuously degraded and rebuilt to respond to the needs of the body. Cells of the osteoblast lineage are responsible for the formation of bone, whereas the resorption of bone tissue is carried out by osteoclasts. LÄS MER