Sökning: "coreceptor tropism"

Visar resultat 6 - 9 av 9 avhandlingar innehållade orden coreceptor tropism.

  1. 6. Receptor use of primate lentiviruses

    Författare :Dalma Vödrös; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; SIV; animal models; receptor use; neutralizing antibodies; CD4-independence;

    Sammanfattning : Human and simian immunodeficiency viruses (HIV and SIV) enter target cells using CD4, the primary cell surface receptor and a secondary receptor, called coreceptor. Coreceptor use of HIV can be related to other biological features of the virus and to the severity of infection as well. LÄS MER

  3. 7. HIV-1 variability in relation to host defence mechanisms and disease outcome

    Författare :Marianne Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; peptides; seroreactivity; genetic variability; pediatric; disease outcome; biological phenotypes; B-chemokines; coreceptors; V3; V2.;

    Sammanfattning : Genetic variability is a major characteristic of HIV-1. Virus variants evolve rapidly, not only globally, but also within single individuals as a result of an error-prone reverse transcriptase, a rapid virus population turnover and selective pressure from the host. LÄS MER

  4. 8. Ultra-deep characterization of viral quasispecies in HIV infection

    Författare :Charlotte Hedskog; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 has the ability to rapidly diversify and adapt to changes in its environment, such as evading the host immune response, altering cell tropism, and developing resistance to antiretroviral drugs. Minority HIV-1 variants have been shown to be of clinical significance, especially those with non-nucleoside reverse transcriptase inhibitor (NNRTI) drug resistance mutations or determinants of CXCR4 phenotype (X4-virus). LÄS MER

  5. 9. The central role of the CD4 T-helper cell in HIV infection : analysis of cell mediated responses and CCR-5 genotypes in HIV-1 infected individuals

    Författare :Ann-Charlotte Leandersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human immunodeficiency virus (HIV) infection is characterized by progressive immunologic dysregulation. The main target of HIV is the CD4 cell resulting in malfunction of the immune system, with a decline in CD4 cells and subsequent development of the acquired immunodeficiency syndrome (AIDS). LÄS MER