Sökning: "anxiety-related behavior"
Visar resultat 11 - 13 av 13 avhandlingar innehållade orden anxiety-related behavior.
11. CYP2C19 and brain development : implications for susceptibility to anxiety in a transgenic mouse model
Sammanfattning : The cytochrome P450-2C19 enzyme is involved in the metabolism of about 10 % of all drugs used today and displays high genetic polymorphism, causing absent, decreased or elevated enzyme activity that divides the population into different metabolic phenotypes. CYP2C19 enzymatic activity is also highly influenced by different substances including drugs and in vivo studies have shown that estradiol and 17α-ethinylestradiol, commonly used in hormone replacement therapy and oral contraceptives, decreased CYP2C19 mediated metabolism in vivo in humans. LÄS MER
12. The pathophysiological roles of kynurenic acid and cytokines in psychiatric illness
Sammanfattning : Kynurenic acid is an astrocyte-derived tryptophan metabolite and a marker of neuroinflammation that antagonizes N-metyl-D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors in the brain. Increased levels have been found in the cerebrospinal (CSF) and brains of patients with schizophrenia and experimental studies have shown that kynurenic acid bi-directionally influences dopaminergic neurotransmission. LÄS MER
13. Central neuropeptide Y (NPH) expression and function : role in stress, experimental anxiety, and cognition
Sammanfattning : Neuropeptide Y (NPY), a 36 amino acid peptide abundantly expressed throughout the mammalian nervous system, has been implicated in experimental anxiety and stress related responses, feeding, and learning and memory. These functions are mediated via different receptor subtype populations (Y1-Y6), all belonging to the G-protein coupled receptor superfamily. LÄS MER
