Sökning: "adenosine diphosphate"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden adenosine diphosphate.
1. Intracellular mechanisms of skeletal muscle fatigue : role of creatine kinase
Sammanfattning : During intense physical activity the maximal power output of skeletal muscles is reduced, a condition described as muscle fatigue. The cause of impaired muscle function seen in fatigue is multifactorial. LÄS MER
2. Platelet activation and aggregation: Clinical and experimental studies
Sammanfattning : Background: Dual antiplatelet therapy with acetylsalicylic acid (ASA) and the adenosine diphosphate (ADP)-receptor antagonist ticagrelor increases the risk of bleeding complications during cardiac surgery. The overall aim of this thesis was to identify and evaluate current and potential methods to reduce and prevent bleeding complications in patients with ongoing antiplatelet therapy. LÄS MER
3. Novel in vivo therapeutic approaches to Escherichia coli O157:H7 infection
Sammanfattning : Shiga toxin (Stx), the unique virulence factor released by enterohemorrhagic Escherichia coli (EHEC), associated with gastrointestinal infection and in severe cases hemolytic uremic syndrome (HUS). Up until now, no effective therapies have been developed to control disease progression. LÄS MER
4. Platelet angiogenic activities and their regulation on endothelial progenitor cell functions
Sammanfattning : Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which contribute importantly to vascular regeneration and endothelium reparation. LÄS MER
5. Effects of high glucose on platelet activation
Sammanfattning : Diabetes mellitus (DM) is associated with increased cardiovascular mortality and morbidity, due to diabetic angiopathy. Hyperglycaemia is one of the factors that may cause platelet dysfunction in diabetic patients. This work investigated the mechanisms underlying hyperglycaemia-induced platelet hyperreactivity and its impact in diabetic patients. LÄS MER