Sökning: "Wnt signalling pathway"

Visar resultat 16 - 20 av 23 avhandlingar innehållade orden Wnt signalling pathway.

1. 16. Novel insights into dishevelled and frizzled function

   Författare :Jana Valnohova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling pathways have been identified in cell-to-cell signal transmission. LÄS MER

3. 17. New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators

   Författare :Ninib Baryawno; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Medulloblastoma is an embryonal tumour that mainly affects children. It is the most common malignant brain tumour in children and accounts for 15% of all childhood brain tumours. It most often presents in the cerebellum and is considered to be a disorder of normal development. LÄS MER

4. 18. Mechanisms for TGF-β-Mediated Regulation of the Actin Filament System and Apoptosis

   Författare :Sofia Edlund; Pontus Aspenström; Maréne Landström; Tommy Andersson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-beta; cytoskeleton; GTPases; mitogen-activated protein kinase kinase 3; TGF-beta-activated kinase 1; Apoptosis; Smad7; beta-catenin; p38 MAPK; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Transforming growth factor-β (TGF-β) is a member of a large superfamily of cytokines which participate in many different types of cellular processes, such as growth inhibition, cell migration, differentiation, cell adhesion, wound healing and immunosuppression. Alterations of TGF-β superfamily signalling results in several different disorders, including bone disease, vascular disease and cancer. LÄS MER

5. 19. Stem cells and development : studies on SUFU and LGR5

   Författare :Maria Hölzl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Embryonic development and cancer formation appear quite different from each other at first glance, yet they share common characteristics such as the reliance on certain signalling pathways. The Hedgehog (HH) and WNT signalling cascades play key roles in a variety of developmental processes where deregulation of these pathways result in a diversity of birth defects. LÄS MER

7. 20. Role of ß-catenin and Leukotriene in Colon Cancer Progression

   Författare :Tavga Salim; Malmö Cellpatologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; β-catenin; E-cadherin; GSK-3β; inflammation; colorectal cancer;

   Sammanfattning : Abstract Colorectal cancer is the third most common cancer worldwide. Deregulation of Wnt/β-catenin signalling pathway is an early hallmark of colon cancer. Were nuclear accumulation of β-catenin is a marker of activated canonical Wnt/β-catenin signaling. One of the risk factors for development of colon cancer is inflammatory bowel disease. LÄS MER