Sökning: "iron overload"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden iron overload.
1. Cadmium exposure and iron status
Sammanfattning : People are exposed to cadmium, a ubiquitous toxic metal, mainly via basic foods such as cereals and vegetables. Cadmium accumulates in the kidney, and renal tubular damage is considered the critical effect. Recently, association with osteoporosis at environmental exposure levels was indicated. LÄS MER
2. Congenital Dyserythropoietic Anemia type III (CDA III) : diagnostics, genetics and morbidity
Sammanfattning : The Congenital Dyserythropoietic Anemias (CDA) are rare hereditary hemolytic disorders with large bi- to multi-nucleated erythroblasts in the bone marrow. Hemolysis is negative in a direct antiglobulin test (DAT). Based on morphology and clinical picture, three major forms of CDAs, type I, II, and III have been defined. LÄS MER
3. Importance of iron overload and steatosis in patients with chronic liver disease
Sammanfattning : This thesis deals with the importance of hepatic iron and fat deposition in the context of chronicliver disease, with special focus on the role of the S65C mutation in the hemochromatosis cryptogenic cirrhosis (CC) in patients evaluated for liver transplantation, the expressions of innate and adaptive immunity in non-alcoholic steatohepatitis (NASH), and the role of the ironregulatory hormone hepcidin in dysmetabolic iron overload (DIO). NAFLD is the most common liver disease in the Western world. LÄS MER
4. Studies of proteins in heme and iron metabolism
Sammanfattning : One aim of the study was to investigate the regulation of the murine erythroid isoform of aminolevulinate synthase (eALAS) protein involved in heme synthesis. Another aim was to characterize the structure of the rat hemochromatosis gene (HFE) gene and its expression in conjunction with other genes involved in the regulation of iron homeostasis during inflammation and iron overload in the rat liver. LÄS MER
5. Clinical and experimental studies on HFE and other genes involved in iron homeostasis
Sammanfattning : In this thesis, the clinical significance of HFE mutations was further investigated, and the molecular mechanisms underlying the disturbed iron homeostasis during hemochromatosis, inflammation and hepatocellular carcinoma were studied in experimental models. Hereditary hemochromatosis (HH) is a prevalent autosomal recessive iron overload disorder caused by increased intestinal absorption and deposition of iron in vital organs, leading to organ damage. LÄS MER