Sökning: "CTNNB1"
Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet CTNNB1.
1. New Insights in Adrenal Tumourigenesis
Sammanfattning : Unilateral cortisol producing adenoma (CPA) is the most common cause of ACTH-independent Cushing’s syndrome and is surgically curable. On the other hand, adrenocortical carcinomas (ACCs) are rare and aggressive tumours. LÄS MER
2. Genetic Alterations and Molecular Signatures in Aldosterone Producing Adenomas
Sammanfattning : Primary Aldosteronism (PA) is caused by autonomous overproduction of aldosterone. Aldosterone is necessary for fluid and ion homeostasis. Aberrant overproduction leads to hypertension and cardiovascular damage. LÄS MER
3. Activating proto-oncogene mutations in human cutaneous melanoma
Sammanfattning : Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary melanoma; 4) vertical growth phase (VGP) primary melanoma; and 5) metastatic melanoma. LÄS MER
4. Molecular studies of endocrine tumors : Insights from genetics and epigenetics
Sammanfattning : Endocrine tumors may be benign or malignant and may occur in any of the hormone producing tissues. They share several biological characteristics, including a low mutation-burden, and may co-occur in several hereditary tumor syndromes. The aim of this thesis was to identify genetic and epigenetic aberrations in endocrine tumors. LÄS MER
5. Endocrine signaling and molecular aberrations in primary hyperparathyroidism
Sammanfattning : Primary hyperparathyroidism is a common endocrine disorder, characterized by an inappropriate increase in serum parathyroid hormone (PTH) levels. It is most often caused by a single benign parathyroid tumor. LÄS MER