Sökning: "TCA"
Visar resultat 16 - 20 av 39 avhandlingar innehållade ordet TCA.
16. Functional aspects of modified nucleosides in tRNA
Sammanfattning : Transfer ribonucleic acids (tRNAs) are extensively modified, especially their anticodon loops. Modifications at position 34 (wobble base) and 37 in these loops affect the tRNAs’ decoding ability, while modifications outside the anticodon loops, e.g. m1A58 of tRNAMeti, may be crucial for tRNA structure or stability. LÄS MER
17. The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity
Sammanfattning : Obesity is a major cause of medical comorbidity with detrimental effects on health span. Fundamentally, obesity is a condition of disrupted energy metabolism, where energy intake chronically exceeds expenditure. Over time, this disruption causes a systemic low-grade inflammation and impairs energy homeostasis. LÄS MER
18. Analysis and Control of Continuous Microaerobic Ethanol Production by Yeast
Sammanfattning : Glucose fermentation by Saccharomyces cerevisiae, and xylose fermentation by Candida utilis and Pichia stipitis, were investigated under microaerobic conditions. A dynamic experimental method named oxygen programmed fermentation (OPF), and a method for microaerobic RQ control in continuous culture have been developed. LÄS MER
19. Metabolic disorders : genes and mechanisms
Sammanfattning : Mitochondrial disorders constitute a subgroup of the large family of rare monogenic diseases called Inborn Errors of Metabolism (IEM), but defects in mitochondrial activity have also been reported in more common and complex pathologies. In the present thesis, I validate new disease-causing variants and study the underlying molecular defects in three different cases of IEM. LÄS MER
20. Models of the metabolism of the pancreatic beta-cell
Sammanfattning : The pancreatic β-cell secretes insulin in response to a raised blood glucose level. Deficiencies in this control system are an important part of the etiology of diabetes. LÄS MER
