Sökning: "TCA"

Visar resultat 21 - 25 av 39 avhandlingar innehållade ordet TCA.

  1. 21. Islet hormonal hypersecretion and metformin’s effect on islet hormonal secretion studied in vitro and in vivo

    Författare :Quan Wen; Anders Forslund; Hannes Manell; Hjalti Kristinsson; Lisa Juntti-Berggren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha cell; carboxypeptidase E; childhood obesity; DRP-1; free fatty acids; glucagon secretion; glucose metabolism; glucose stimulated insulin secretion; human islets; hyperinsulinemia; metformin; mitochondrial fission; oral glucose tolerance test OGTT ; prohormone convertase; proinsulin; proinsulin to insulin ratio PI:I ;

    Sammanfattning : Childhood obesity has surged globally. Elevated levels of free fatty acids contribute to hyperinsulinemia, hyperproinsulinemia, and hyperglucagonemia connected with both obesity and type 2 diabetes mellitus (T2DM). Metformin has beneficial effects on islets by influencing metabolism and reducing stress-induced cell death. LÄS MER

  3. 22. Nitrogen and Redox Metabolism in Saccharomyces cerevisiae

    Författare :Eva Albers; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Saccharomyces cerevisiae; glutamate; protein expression; anaerobic physiology; nitrogen metabolism; redox; serine;

    Sammanfattning : Anaerobic conversion of glucose to ethanol by the yeast Saccharomyces cerevisiae has been studied. Glycerol is formed as a by-product in order to maintain the overall redox balance. LÄS MER

  4. 23. On the efficacy and prescription of serotonin reuptake inhibitors

    Författare :Alexander Lisinski; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antidepressants; antidepressive agents; major depressive disorder; selective serotonin reuptake inhibitor; serotonin and noradrenaline reuptake inhibitor; tricyclic antidepressant;

    Sammanfattning : This thesis addresses several controversial issues regarding commonly used antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs). To this end, patient-level data from 28 placebo-controlled trials on SSRIs and 13 corresponding trials on the SNRI duloxetine, were requested and obtained. LÄS MER

  5. 24. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

    Författare :Sarah Piel; Klinisk neurofysiologi; []
    Nyckelord :mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

    Sammanfattning : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. LÄS MER

  7. 25. Distributed Monitoring and Resource Management for Large Cloud Environments

    Författare :Fetahi Zebenigus Wuhib; Rolf Stadler; Danny Raz; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; decentralized management; engineering protocols; distributed monitoring; resource management; Telecommunication; Telekommunikation; Computer science; Datalogi;

    Sammanfattning : Over the last decade, the number, size and complexity of large-scale networked systems has been growing fast, and this trend is expected to accelerate. The best known example of a large-scale networked system is probably the Internet, while large datacenters for cloud services are the most recent ones. LÄS MER