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Visar resultat 21 - 21 av 21 avhandlingar som matchar ovanstående sökkriterier.

1. 21. Aldehyde toxicity in human oral epithelium

   Författare :Jan Anders Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Oral epithelium; cell cultures; toxicity; transformation; aldehydes; thiols; ADH3;

   Sammanfattning : Human oral epithelium is an established target for aldehyde toxicity, including from usage of tobacco, intake of foods and fluids, leaching of dental materials, and from mouth inhalation of aldehydes in the work environment. Following establishment of culture/exposure protocols for oral cell cultures, toxicity mechanisms and risk of malignant transformation from aldehyde exposure was investigated, including the metabolic defense offered by alcohol dehydrogenase 3 (ADH3) against formaldehyde toxicity. LÄS MER