Sökning: "nuclear rDNA"
Visar resultat 1 - 5 av 20 avhandlingar innehållade orden nuclear rDNA.
1. On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control
Sammanfattning : Aging is characterized by a build-up of damage in organisms ranging from protists to multi-cellular species. This damage adversely affects core components such as DNA and proteins which are necessary to sustain life. LÄS MER
2. The lichen genus Candelariella in western North America
Sammanfattning : The lichen genus Candelariella comprises crustose to small squamulose members of the family Candelariaceae. The genus currently includes c. 50 species world-wide but few studies have treated the taxonomy within this group. In the present thesis the taxonomy of the genus in western North America is treated. LÄS MER
3. Role of c-Myc in the regulation of rDNA transcription by RNA polymerase I
Sammanfattning : Ribosomal biogenesis and protein translation are finely coordinated with cell proliferation. All three RNA polymerases Pol I, II, and III are utilized for highly efficient and accurate ribosome production. The transcriptional activity of Pol I has been found to be a key determinant for ribosome biogenesis. LÄS MER
4. Insights into the roles of the essential Pfh1 DNA helicase in the nuclear and mitochondrial genomes
Sammanfattning : Eukaryotic cells have two sets of genomes, the nuclear and mitochondrial, and both need to be accurately maintained. Also, the rate of transcription must be precisely regulated in these genomes. However, there are many natural barriers that dysregulate these processes. LÄS MER
5. Not just protein factories : role of ribosome biogenesis as an architect of epithelial-mesenchymal transition and breast cancer progression
Sammanfattning : RNA polymerase I (Pol I)-mediated transcription of ribosomal DNA (rDNA) is considered to be the rate-limiting step in ribosome biogenesis and is a well-known hallmark of cell growth and proliferation. The process of synthesizing new ribosomes is executed by the coordination of multiple complex processes in the nucleolus. LÄS MER