Sökning: "Phosphoproteomics"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet Phosphoproteomics.

  1. 1. Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome

    Författare :Valentina Siino; Institutionen för immunteknologi; []
    Nyckelord :Phosphoproteomics; mass spectrometry; brain disorders; neurobiology; phosphorylation;

    Sammanfattning : Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. LÄS MER

  3. 2. Finding order in chaos : Dissecting single-cell heterogeneity in space and time

    Författare :Christian Gnann; Emma Lundberg; Manuel D Leonetti; Lucas Pelkmans; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-genetic single-cell heterogeneity; cell cycle; metabolism; imaging-based subcellular proteomics; phosphoproteomics; icke-genetisk single-cell heterogenitet; cellcykel; metabolism; bildbaserad subcellulär proteomik; fosfoproteomik; Biotechnology; Bioteknologi;

    Sammanfattning : The cell is the smallest unit of life and contains DNA, RNA, proteins and a variety of other macromolecules. In recent years, technological advances in the field of single cell biology have revealed a staggering amount of phenotypic heterogeneity between cells in a population, which were previously considered homogenous. LÄS MER

  4. 3. Characterizing cancer cell signaling at the protein level : from targeted to proteome and phosphoproteome­‐wide analyses

    Författare :Elena Panizza; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Proteins are the effectors of cellular functions and the constituting elements of cellular signaling cascades. The ability to analyze the abundances and the dynamics of proteins is central to dissect cellular signaling and its effects on cell physiology. LÄS MER

  5. 4. Defence and signalling in Potato-Phytophthora infestans interactions

    Författare :Ashfaq Ali; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phytophthora infestans; Plant defence; hypersensitive response; resistance; susceptibility;

    Sammanfattning : Potato is one of the major food crops and its yield is severely affected by late blight disease caused by Phytophthora infestans. P. infestans has the ability to manipulate plant defence signalling by secreting effector molecules causing so called effector triggered susceptibility. LÄS MER

  7. 5. Mechanistic Implications and Characterization of Anaplastic Lymphoma Kinase (ALK) mutations in Neuroblastoma

    Författare :Damini Chand; Bengt Hallberg; Christer Larsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; ALK; crizotinib; receptor tyrosine kinase; molekylärbiologi; Molecular Biology;

    Sammanfattning : Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion partner of nucleophosmin in Anaplastic large cell lymphoma in 1994. ALK is involved in myriad of cancers including neuroblastoma which is the most common extracranial solid tumor affecting young children. LÄS MER