Sökning: "PDGFRb"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet PDGFRb.

  1. 1. The role of PDGF-B in brain blood vessels

    Författare :Khayrun Nahar; Christer Betsholtz; Jean-Baptiste Demoulin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PFBC; PDGFB; PDGFRB; Brain vasculature; Mural cells;

    Sammanfattning : The development of blood vessels is dependent on several molecular cues to form properly. A functional PDGF-B/PDGFR-b signaling is paramount for the investment of mural cells, that provide with support, to the developing vasculature. LÄS MER

  3. 2. Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members

    Författare :Daniel Wetterskog; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Aims: The platelet-derived growth factor ?-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. LÄS MER

  4. 3. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor

    Författare :Anders Hackzell; Göteborgs universitet; []
    Nyckelord :PDGF; cell cycle; p73; p53; SV40; NF-Y; Sp1; Myc;

    Sammanfattning : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. LÄS MER

  5. 4. Regulation of PDGFRβ signaling 

    Författare :Piotr Wardęga; Johan Lennartsson; Edvard Smith; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PDGF; HD-PTP; Alix; Cbl; Ub; Fer; Y857; Y771; downregulation; degradation; ubiquitination; activation loop; Cell and molecular biology; Cell- och molekylärbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Platelet-derived growth factor (PDGF) isoforms, which bind to closely related a- and b-tyrosine kinase receptors, induce migration, proliferation, survival and differentiation of mesenchymal cells. They signal by the active receptor attracting Src homology 2 (SH2) domain containing proteins, which subsequently initiate a set of signaling pathways. LÄS MER

  7. 5. Unraveling the role of NOTCH3 dysfunction in disease and for therapy development : a focus on CADASIL

    Författare :Daniel V Oliveira; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Notch signaling pathway, including the Notch3 receptor, is involved in many pivotal contexts of cell signaling and cell fate determination processes during development and in adulthood. Different mutations in the NOTCH3 receptor, which is highly expressed in vascular smooth muscle cells (VSMC), are associated with various diseases, including developmental disorders, several forms of cancer, and vascular dementia. LÄS MER