Sökning: "P1 antigen"

Visar resultat 6 - 9 av 9 avhandlingar innehållade orden P1 antigen.

  1. 6. Post-translational modifications of myelin oligodendrocyte glycoprotein in CNS autoimmunity

    Författare :Andreas Warnecke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmunity towards components of the central nervous system (CNS) is a driving factor of nerve demyelination in Multiple Sclerosis (MS). The etiology of autoimmunity in MS pathogenesis remains elusive, but a combination of genetic predisposition and environmental triggers is theorized to initiate this complex disease. LÄS MER

  3. 7. Studies on glycosphingolipids in infection, immunity and differentiation

    Författare :John Benktander; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycosphingolipids; Mass spectrometry; Helicobacter pylori BabA; Vibrio cholerae; Human embryonic stem cells; Glycosyltransferase; PX2;

    Sammanfattning : Cell surface glycoconjugates play a role in many biological processes such as responses to microbial infections, cell-cell interactions, differentiation, and inflammatory responses. The present work is focused on structural characterization of glycosphingolipids with potential roles in adhesion of Helicobacter pylori and Vibrio cholerae, differentiation of human pluripotent stem cells, and as blood group determinants. LÄS MER

  4. 8. The importance of major histocompatibility complex class II genes for the development of autoimmune inflammation

    Författare :Ulrica Brunsberg; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serology; Immunology; Mhc polymorphism arthritis evolution; Immunologi; serologi;

    Sammanfattning : In this thesis the role of major histocompatibility complex (Mhc) class II molecules in development of autoimmune disease such as rheumatoid arthritis (RA), was studied. By combining an experimental model for RA, collagen type II induced arthritis (CIA), with molecular biology methods the importance of polymorphism in Mhc class II genes for disease development was investigated. LÄS MER

  5. 9. Positional identification and functional analysis of genes regulating autoimmune arthritis

    Författare :Anthony Chun Yeung Yau; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA). However, even the genetic association between MHC and RA was known more than 40 years ago, we still have not fully explained the functional roles of the MHC genes and identified the underlying specific polymorphisms. LÄS MER