Sökning: "NF-kappaB"

Visar resultat 11 - 15 av 47 avhandlingar innehållade ordet NF-kappaB.

  1. 11. Tec family kinases : transcriptional and posttranslational regulation

    Författare :Liang Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tec family tyrosine kinases consist of five members: Btk, Itk, Tec, Rlk/Txk and Bmx. These kinases are highly expressed in hematopoietic cells, including B cells, T cells and mast cells. LÄS MER

  3. 12. Pivotal role of the nuclear receptor PPARgamma in colon epithelial cells

    Författare :Emmelie Å Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : When symbiosis between the residential intestinal flora and the epithelial cells of the gastrointestinal tract is broken one endpoint may be chronic inflammation, e.g. Inflammatory Bowel Disease (IBD). The disruption of the epithelial lining elicits activation of NF-kappaB and secretion of potent inflammatory mediators. LÄS MER

  4. 13. Molecular consequences of cellular UDP-glucose deficiency

    Författare :Juan Carlos Higuita V; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A Chinese hamster fibroblast mutant cell line, deficient in UDP-glucose (UDPG), denoted as Qc, and its counterpart cell line with normalized levels of UDPG (G3), were used to determine some molecular consequences of chronic UDPG deficiency. The UDPG deficient cells lacked glycogen, had elevated rates of glucose uptake and a decreased capacity to synthesize glycogen after 120h of culture. LÄS MER

  5. 14. Effects of glucocorticoids or beta 2-agonists on inflammatory responses induced by organic dust in vitro and in vivo

    Författare :Alexandra Ek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Exposure of healthy subjects in a swine barn causes an acute inflammatory response in the airways and an increase in bronchial responsiveness to methacholine. The aim of this thesis was to study the mechanisms by which glucocorticoids or Beta2-agonists interfere with the inflammatory response following swine house dust-exposure both in vitro and in vivo. LÄS MER

  7. 15. Synaptic plasticity in drug abuse disorders : studies of the human post-mortem brain

    Författare :Anna Ökvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug addiction is a chronic disorder characterized by craving and compulsive drug use despite adverse consequences and high rates of relapse during periods of abstinence. Therapeutic interventions for most addiction disorders are limited today, partly because the underlying neurobiology is still unknown. LÄS MER