Sökning: "Resistome"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Resistome.

  1. 1. Exploring the Ciprofloxacin Resistome

    Författare :Linnéa Garoff; Diarmaid Hughes; Jesús Blázquez; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; Experimental evolution; Ciprofloxacin; Escherichia coli; Mikrobiologi; Microbiology;

    Sammanfattning : This thesis presents an exploration of the resistance evolution in Escherichia coli towards the antibiotic ciprofloxacin. High level ciprofloxacin resistance is typically acquired by an accumulation of mutations and plasmid borne genes reducing drug target binding, increasing drug efflux, and modifying the drug. LÄS MER

  3. 2. Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements

    Författare :Mohammad Razavi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environment; Metagenomics; Antibiotic resistance; Mobile genetic elements; Insertion sequences; Integron; Resistome; Next-generation sequencing;

    Sammanfattning : Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental bacteria. LÄS MER

  4. 3. From Physicochemical Features to Interdependency Networks : A Monte Carlo Approach to Modeling HIV-1 Resistome and Post-translational Modifications

    Författare :Marcin Kierczak; Jan Komorowski; Anna Tramontano; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; HIV-1; resistome analysis; drug resistance; predicting PTMs; molecular interdependency networks; MCFS-ID; feature selection; interactome; machine-learning; rough sets; Bioinformatics; Bioinformatik; Computer Science; datavetenskap; Biology; with specialization in structural biology; biologi; med inriktning mot strukturbiologi;

    Sammanfattning : The availability of new technologies supplied life scientists with large amounts of experimental data. The data sets are large not only in terms of the number of observations, but also in terms of the number of recorded features. LÄS MER

  5. 4. A world inside : Gastrointestinal microbiota in healthy Swedish children at day care centers and aspects on antibiotic resistance, enteric pathogens and transmission

    Författare :Johan Kaarme; Tryggve Nevéus; Björn Olsen; Jonas Ludvigsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ESBL; VRE; enteropathogens; antibiotic resistance; children; preschool; Pediatrik; Pediatrics;

    Sammanfattning : Antibiotic resistance is a growing threat to human health and is defined by the World Health Organization as a crisis that must be managed with the utmost urgency. Antibiotic resistant bacteria increase both mortality and morbidity and have a great impact on the global economy. LÄS MER

  7. 5. New AI-based methods for studying antibiotic-resistant bacteria

    Författare :Juan Salvador Inda Díaz; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transformers; Antibiotic Resistance; Infectious Diseases; Metagenomics; Data-driven Diagnostics;

    Sammanfattning : Antibiotic resistance is a growing challenge for human health, causing millions of deaths worldwide annually. Antibiotic resistance genes (ARGs), acquired through mutations in existing genes or horizontal gene transfer, are the primary cause of bacterial resistance. LÄS MER